Selected Publications


Recent Refereed Research Articles
  1. Pulukkunat D.K., Gopalan, V. (2008) Studies on Methanocaldococcus jannaschii RNase P reveal insights into the roles of RNA and protein cofactors in RNase P catalysis. Nucleic Acids Research. 36: 4172-4180.
  2. Kawamoto, S. A., Sudhahar, C. G., Hatfield, C., Sun, J., Behrman, E. J. and Gopalan, V. (2008) Studies on the mechanism of inhibition of bacterial RNase P by aminoglycoside derivatives. Nucleic Acids Research. 36: 697-704.
  3. Tsai, H-Y., Pulukkunat, D. K., Woznick, W. and Gopalan, V. (2006) Functional reconstitution and characterization of Pyrococcus furiosus RNase P. Proc. Natl. Acad. Sci. USA 103: 16147-16152.
  4. Rangarajan, S., Raj, M. L. S., Hernandez, J. M., Grotewold, E. and Gopalan, V. (2004) RNase P-mediated disruption of gene expression in maize cells. Biochem J. 380: 611-616.
  5. Boomershine,W. P., McElroy, C. A., Tsai, H. Y., Wilson, R. C., Gopalan, V. and Foster, M. P. (2003) Structure of Mth11/MthRpp29, an essential protein subunit of archaeal and eukaryal RNase P. Proc. Natl. Acad. Sci. USA 100: 15398-15403.
  6. Boomershine, W., Raj, M. L. S., Gopalan, V. and Foster, M. P. (2003) Preparation of uniformly labeled NMR samples in Escherichia coli under the tight control of the araBAD promoter: Expression of an archaeal homolog of the RNase P Rpp29 protein. Protein Expression and Purification 28: 246-251.
  7. Tsai, H-Y., Masquida, B., Biswas, R., Westhof, E. and Gopalan, V. (2003) Molecular modeling of the three-dimensional structure of the bacterial RNase P holoenzyme. Journal of Molecular Biology 325: 661-675.
  8. Jovanovic, M., Sanchez, R., Altman, S. and Gopalan, V. (2002) Elucidation of structure-function relationships in the protein subunit of bacterial RNase P using a genetic complementation approach. Nucleic Acids Research 30: 5065-5073.
  9. Guerrier-Takada, G., Eder, P. S., Gopalan, V. and Altman, S. (2002) Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P. RNA 8: 290-295.
  10. Eubank, T., Biswas, R., Jovanovic, M., Litovchick, A., Lapidot, A. and Gopalan, V. (2002) Inhibition of bacterial RNase P by modified aminoglycosides. FEBS Lett. 511: 107-112.
  11. Tsai, H-Y., Lai, L. B. and Gopalan, V. (2002) A modified pBluescript-based vector for facile cloning and transcription of RNAs. Anal. Biochem. 303: 214-217.
  12. Stephen Raj, M. L., Pulukkunat, D. K., Reckard, J. F., Thomas, G. and Gopalan, V. (2001) Cleavage of bipartite substrates by rice and maize RNase P: Application to targeted degradation of mRNAs in plants. Plant Physiol. 125: 1187-1190.
  13. Wu, C-W., Eder, P. S., Gopalan, V. and Behrman, E. J. (2001) Kinetics of coupling reactions that generate monothiophosphate disulfides Implications for modification of RNAs. Bioconjugate Chemistry 12: 842-844.
  14. Biswas, R., Ledman, D., Fox, R. O., Altman, S. and Gopalan, V. (2000) Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using disulfide-linked EDTA-Fe. J. Mol. Biol. 296: 19-31.

Recent Review/Commentary Articles Published in Journals or Books
  1. Behrman E.J. and Gopalan, V. (2008) Phosphoenolpyruvate: An end to hand-waving. BAMBED. (in press).
  2. Gopalan, V. (2007) Uniformity amid diversity in RNase P. Proc. Natl. Acad. Sci. USA 104: 2031-2032.
  3. Gopalan, V. and Altman, S. (2007) Ribonuclease P: structure and catalysis. In "The RNA World" (Gesteland, R. F., Cech, T. R. and Atkins, J. F., Eds.), Third edition, Cold Spring Harbor Laboratory Press, New York, NY.
  4. Behrman, E. J. and Gopalan, V. (2007) The anomeric specificity of enzymes which act on sugars. J. Chem. Ed. 84: 1608.
  5. Lai, L. B., Gopichandran, V., and Gopalan, V. (2005) Tangier disease: A disorder in the reverse cholesterol transport pathway. In "Clinical Studies in Medical Biochemistry", (Glew, R. H. and Rosenthal, M. D., Eds.), pp. 159-166, Oxford University Press, New York, NY.
  6. Gopichandran, V., Lai, L. B. and Gopalan, V. (2005) Protein-energy malnutrition. In "Clinical Studies in Medical Biochemistry", (Glew, R. H. and Rosenthal, M. D., Eds.), pp. 255-367, Oxford University Press, New York, NY.
  7. Behrman, E. J. and Gopalan, V. (2005) Cholesterol and plants. J. Chem. Ed. 82: 1791-1793.
  8. Eder, P. S., Hatfield, C., Vioque, A. and Gopalan, V. (2003) Bacterial RNase P as a potential target for novel anti-infectives. Curr. Op. Invest. Drugs 4: 937-943.
  9. Pulukkunat, D. K., Stephen Raj, M. L., Pattanayak, D., Lai, L. B. and Gopalan, V. (2003) Exploring the potential of plant RNase P as a functional genomics tool. Invited article for book entitled "Functional genomics: Methods and Protocols" (Grotewold, E., Ed.), pp. 295-309, Humana Press, Totowa, NJ.
  10. Gopalan, V., Vioque, A. and Altman, S. (2003) RNase P: Variations and uses. In "Life Sciences for the 21st Century" (Keinan, E., Schechter, I., and Sela, M., Eds.), pp. 49-59, Wiley-VCH, Weinheim, GERMANY.
  11. Gopalan, V., Vioque, A. and Altman, S. (2002) RNase P: variations and uses. J. Biol. Chem. 277: 6759-6762.
  12. Biswas, R., Kuhne, H., Brudvig, G. and Gopalan, V. (2001) Use of EPR spectroscopy to study macromolecular structure and function. Science Progress 84: 45-68.
  13. Altman, S., Gopalan, V. and Vioque, A. (2000) Varieties of RNase P: A nomenclature problem? RNA 6: 1689-1694.

the gopalan group




c o n t a c t
--------------------------------
Dr. Venkat Gopalan, Ph.D.
Associate Professor of Biochemistry
The Ohio State University
707 Biological Sciences Building
484 West 12th Avenue
Columbus, OH 43210

Office Phone:  (614) 292-1332
Laboratory Phone:  (614) 292-2036
Fax:  (614) 292-6773
Email:  gopalan.5@osu.edu


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