Assistant Professor, Departments of Chemistry and Biochemistry
Member, Ohio State Biochemistry Program
Member, Biophysics Graduate Program
Member, Chemistry-Biology Interface Training Program
Member, Cellular, Molecular and Bichemical Sciences Program
Member, Microbiology Graduate Program

Contact Information

Biosketch

Education & Training

Other Experience & Professional Memberships

Honors

Teaching

Link to Publications

Funding

U54 NS058183-06                       Douglas Cerasoli, PI              9/30/2011-8/31/2014
NIH/NINDS (CounterACT)
Center for Catalytic Bioscavenger Medical Defense Research II: Discovery, Formulation and Preclinical Evaluation
Thomas J. Magliery, co-PI

• Project 2: Engineering PON1 and OPH for altered substrate specificity and improved drug-like properties: rational and computational approaches, Magliery, PI, Christopher Hadad and P. George Wang, co-PIs
• Protein Production Core, Magliery, PI
• Administrative Core, Magliery, co-PI (PI of subcontract)

R01 GM083114-02S1                  Thomas Magliery, PI             9/30/2009-8/31/2011
NIH/NIGMS
ARRA Supplement to Combinatorial biophysics: understanding protein stability with library approaches
• No-cost extension to 8/31/2012

R01 GM083114                           Thomas Magliery, PI              8/15/2008-5/31/2013
NIH/NIGMS
Combinatorial biophysics: understanding protein stability with library approaches

U54 NS058183 0006                   Thomas Magliery, PI              9/30/2006-5/31/2011
NIH/NINDS (CounterACT)
Center for Catalytic Bioscavenger Medical Defense Research (David Lenz, PI)
Subcontract: Engineering and Expression of Organophosphate Hydrolases as Protein Therapeutics: Engineering for Drug-Like Properties, Expression in Microalgae, and Protein Glycosylation
Richard Sayre, George Wang, co-PIs
• No-cost extension to 3/1/2012

U54 NS058183 0004                   Christopher Hadad, PI            9/30/2006-5/31/2011
NIH/NINDS (CounterACT)
Center for Catalytic Bioscavenger Medical Defense Research (David Lenz, PI)
Subcontract: Mechanistic, Kinetic, Spectroscopic and Computational Evaluations of OP Hydrolysis Activity of Enzymes
Terry Gustafson, Thomas Magliery, Matthew Platz, co-PIs
• No-cost extension to 3/1/2012

Biography

Thomas J. Magliery was born in Oak Park, Illinois, in 1974 and grew up outside of Chicago and Indianapolis. He conducted medical genetics research with M. Ed Hodes at the Indiana University Medical Center in Indianapolis, leading to a semifinalist-winning project in the Westinghouse Science Search in 1992. Magliery majored in chemistry at Kenyon College in Gambier, Ohio, graduating in 1996. There he conducted research in molecular biology and bioinorganic chemistry. His honors thesis work with Rosemary Marusak involved the synthesis of diimides related to EDTA and investigation of the role of their iron-chelate hydrolysis products in hydoxyl-radical damage of DNA. In 1994, he spent a summer at Penn State University with Gordon Hamilton as an NSF REU fellow working towards the synthesis of a putative intermediate in the conversion of ascorbic acid to S-oxalins. Magliery graduated with highest honors in chemistry, distinction on the senior exercise in chemistry, summa cum laude and with election to Phi Beta Kappa and Sigma Xi.

Magliery received his Ph.D. (2001) in chemistry from the University of California, Berkeley, under the direction of Peter G. Schultz. As an NSF Pre-Doctoral Fellow, he worked on several key aspects of engineering living bacteria for the site-specific insertion of unnatural amino acids, including: engineering the first "orthogonal" tRNA and aminoacyl-tRNA synthetase for use in E. coli; development of library and selection technology that lead to the first bacteria with expanded genetic codes; and selection and characterization of tRNAs capable of decoding 4-base codons. He moved to The Scripps Research Institute in La Jolla, California, with Schultz in 1999.

Joining Lynne Regan in Molecular Biophysics & Biochemistry at Yale University in 2001, Magliery introduced a cell-based screen for the four-helix bundle protein Rop and demonstrated its use in sorting libraries of protein variants with randomized hydrophobic cores. He expanded a GFP fragment reassembly screen for the detection of protein-protein interactions in bacteria, screening for antiparallel leucine zipper interactions and investigating kinetic aspects of GFP fragment reassembly. He also used a statistical free energy approach to improve the design of "consensus" tetratricopeptide repeat (TPR) motifs, discovering in the process how sequence variation can be used to understand and predict ligand binding sites in proteins. Magliery was an NIH Postdoctoral Fellow.

Magliery joined the faculty of The Ohio State University in the fall of 2005 as an Assistant Professor in the Departments of Chemistry and Biochemistry. He is a member of the Ohio State Biochemistry Program, the Biophysics Graduate Program, the Microbiology Graduate Program, the Chemistry-Biology Interface Training Program, and the Cellular, Molecular and Biochemical Sciences Program. Click here for information on his current research.