» Thomas J. Magliery
» Research
» News
» Publications
» People
» Links

Department of Chemistry & Biochemistry
The Ohio State University
1043 Evans Laboratory
100 West 18th Ave.
Columbus, Ohio 43210-1185
(614) 247-8425 office
(614) 292-1685 fax
magliery.1@osu.edu

Copyright © 2005-2013, Thomas J. Magliery. All rights reserved. No part of this website may be reproduced without explicit written permission from the author.

 
» Thomas J. Magliery

Associate Professor, Department of Chemistry & Biochemistry
Member, Ohio State Biochemistry Program (OSBP)
Member, Biophysics Graduate Program
Member, Microbiology Graduate Program
Member, Chemistry-Biology Interface Training Program (CBIP)
Member, Cellular, Molecular and Bichemical Sciences Training Program (CMBP)

Contact Information

E-mail magliery.1@osu.edu

Department of Chemistry & Biochemistry
The Ohio State University
1043 Evans Laboratory
100 W. 18th Ave.
Columbus, OH 43210-1185

(614) 247-8425 office
(614) 292-1685 departmental fax

Tami Gerrard-Sizemore
Administrative Assistant

Email tsizemor@chemistry.ohio-state.edu
(614) 247-7661 office
(614) 292-1685 departmental fax

Biosketch

Education & Training

1996 Kenyon College, Gambier, Ohio, A.B., Chemistry (Rosemary A. Marusak)
2001 University of California, Berkeley, Ph.D., Chemistry (Peter G. Schultz)
1999-2001 The Scripps Research Institute, La Jolla, California, Graduate research, Chemistry (Peter. G. Schultz)
2001-2005 Yale University, New Haven, Connecticut, NIH Postdoctoral Fellow, Molecular Biophysics & Biochemistry (Lynne Regan)

Positions

2013- Associate Professor, Department of Chemistry & Biochemistry, The Ohio State University, Columbus
2005-2013 Assistant Professor, Departments of Chemistry & Biochemistry, The Ohio State University, Columbus

Other Experience

2013-2015 Member, Nominating Committee, Protein Society
2010-2013 Ad hoc reviewer for NIH CounterACT SEP (R21, U01, U54)
2008- Member, Editorial Advisory Board, Molecular BioSystems
2007 X-Ray Methods in Structural Biology, Cold Spring Harbor Laboratory, New York
2005-2008 Board of Directors, Sigma Xi, Ohio State Chapter

Honors

2011 James M. Siddens Award for Distinguished Faculty Advising, OSU
2008 Finalist, Distinguished Undergraduate Research Mentor of the Year Award, OSU
2006 Finalist, College of Arts & Sciences Outstanding Teaching Award, OSU
2002-2005 NIH Postdoctoral Fellowship, NRSA F32, NIGMS
1997-2000 NSF Predoctoral Fellowship
1996 Carl Djerassi Award in Chemistry, Kenyon College
1996 Sigma Xi
1996 Phi Beta Kappa, Beta of Ohio, Kenyon College
1995 Barry Goldwater Scholarship
1994 Robert Tomsich Excellent in Science Award, Kenyon College
1992-1996 Honor/Science Scholarship, Kenyon College

Teaching

Semester Calendar (2012-present)

Chemistry 2510 Organic Chemistry I Spring 2013
Biochemistry 8990 Special Topics: Combinatorial Approaches in Chemistry & Biology Autumn 2013 (II)

Quarter Calendar (2005-2012)

Chemistry 102 Elementary Chemistry II Winter 2009
Chemistry 251 Organic Chemistry I Autumn 2005, Winter 2007, Autumn 2008, Winter 2011
Chemistry 990 Special Topics: Combinatorial Approaches in Chemistry & Biology Winter 2006, Winter 2008, Winter 2010, Winter 2012
Biochemistry 721.03 Physical Biochemistry III Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012

Link to Publications

Funding

Current Funding

U54 NS058183-06                       Douglas Cerasoli, PI              9/30/2011-8/31/2014
NIH/NINDS (CounterACT)
Center for Catalytic Bioscavenger Medical Defense Research II: Discovery, Formulation and Preclinical Evaluation
Thomas J. Magliery, co-PI

  • Project 2: Engineering PON1 and OPH for altered substrate specificity and improved drug-like properties: rational and computational approaches, Magliery, PI, Christopher Hadad and P. George Wang, co-PIs
  • Protein Production Core, Magliery, PI
  • Administrative Core, Magliery, co-PI (PI of subcontract)

R01 GM083114                           Thomas Magliery, PI              8/15/2008-5/31/2013
NIH/NIGMS
Combinatorial biophysics: understanding protein stability with library approaches
• No-cost extension to 5/31/2014

Recent Funding (Last 5 Years)

HHSN261201200059C                                                             6/1/2013-8/14/2013
Enlyton, Ltd. (subcontract to NCI SBIR)
A Tunable Tumor Targeting Agent for SPECT Imaging

R01 GM083114-02S1                  Thomas Magliery, PI             9/30/2009-8/31/2011
NIH/NIGMS
ARRA Supplement to Combinatorial biophysics: understanding protein stability with library approaches
• No-cost extension to 8/31/2012

U54 NS058183 0006                   Thomas Magliery, PI              9/30/2006-5/31/2011
NIH/NINDS (CounterACT)
Center for Catalytic Bioscavenger Medical Defense Research (David Lenz, PI)
Subcontract: Engineering and Expression of Organophosphate Hydrolases as Protein Therapeutics: Engineering for Drug-Like Properties, Expression in Microalgae, and Protein Glycosylation
Richard Sayre, George Wang, co-PIs
• No-cost extension to 9/29/2011

U54 NS058183 0004                   Christopher Hadad, PI            9/30/2006-5/31/2011
NIH/NINDS (CounterACT)
Center for Catalytic Bioscavenger Medical Defense Research (David Lenz, PI)
Subcontract: Mechanistic, Kinetic, Spectroscopic and Computational Evaluations of OP Hydrolysis Activity of Enzymes
Terry Gustafson, Thomas Magliery, Matthew Platz, co-PIs
• No-cost extension to 9/29/2011

Biography

Thomas J. Magliery was born in Oak Park, Illinois, in 1974 and grew up outside of Chicago and Indianapolis. He conducted medical genetics research with M. Ed Hodes at the Indiana University Medical Center in Indianapolis, leading to a semifinalist-winning project in the Westinghouse Science Search in 1992. Magliery majored in chemistry at Kenyon College in Gambier, Ohio, graduating in 1996. There he conducted research in molecular biology and bioinorganic chemistry. His honors thesis work with Rosemary Marusak involved the synthesis of diimides related to EDTA and investigation of the role of their iron-chelate hydrolysis products in hydoxyl-radical damage of DNA. In 1994, he spent a summer at Penn State University with Gordon Hamilton as an NSF REU fellow working towards the synthesis of a putative intermediate in the conversion of ascorbic acid to S-oxalins. Magliery graduated with highest honors in chemistry, distinction on the senior exercise in chemistry, summa cum laude and with election to Phi Beta Kappa and Sigma Xi.

Magliery received his Ph.D. (2001) in chemistry from the University of California, Berkeley, under the direction of Peter G. Schultz. As an NSF Pre-Doctoral Fellow, he worked on several key aspects of engineering living bacteria for the site-specific insertion of unnatural amino acids, including: engineering the first "orthogonal" tRNA and aminoacyl-tRNA synthetase for use in E. coli; development of library and selection technology that led to the first bacteria with expanded genetic codes; and selection and characterization of tRNAs capable of decoding 4-base codons. He moved to The Scripps Research Institute in La Jolla, California, with Schultz in 1999.

Joining Lynne Regan in Molecular Biophysics & Biochemistry at Yale University in 2001, Magliery introduced a cell-based screen for the four-helix bundle protein Rop and demonstrated its use in sorting libraries of protein variants with randomized hydrophobic cores. He expanded a GFP fragment reassembly screen for the detection of protein-protein interactions in bacteria, screening for antiparallel leucine zipper interactions and investigating kinetic aspects of GFP fragment reassembly. He also used a statistical free energy approach to improve the design of "consensus" tetratricopeptide repeat (TPR) motifs, discovering in the process how sequence variation can be used to understand and predict ligand binding sites in proteins. Magliery was an NIH Postdoctoral Fellow.

Magliery joined the faculty of The Ohio State University in the fall of 2005 as an Assistant Professor in the Departments of Chemistry and Biochemistry, and he was promoted to Associate Professor in the merged Department of Chemistry & Biochemistry in 2013. He is a member of the Ohio State Biochemistry Program, the Biophysics Graduate Program, the Microbiology Graduate Program, the Chemistry-Biology Interface Training Program, and the Cellular, Molecular and Biochemical Sciences Program. Click here for information on his current research.