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Department of Chemistry & Biochemistry
The Ohio State University
1043 Evans Laboratory
100 West 18th Ave.
Columbus, Ohio 43210-1185
(614) 247-8425 office
(614) 292-1685 fax
magliery@chemistry.ohio-state.edu

Copyright © 2005-2013, Thomas J. Magliery. All rights reserved. No part of this website may be reproduced without explicit written permission from the author.

 
» News

2013

Undergraduates to present at Meek, NMS and Denman Forums

Undergraduate researchers David Alten, Kiersten Lessig and Chris Reyes will present posters at the departmentla Meek Lecture on Mar. 7, at the college-wide NMS Research Forum on Mar. 20, and at the university-wide Denman Undergraduate Research Forum on Mar. 28.

Magliery presents seminar at Youngstown State Chemistry

Prof. Magliery is presenting a seminar at Youngstown State Chemistry on Feb. 15.

Hari presents RFG seminar

Sanjay Hari, an Honors undergraduate researcher from the Magliery lab who graduated in 2008, returned to his alma mater to give a seminar in the Chemical & Molecular Biology/Structural Biology & Biophysics Research Focus Group series on Feb. 7. Hari is currently a senior graduate student with Dustin Maly at University of Washington, Seattle, in the Department of Chemistry and the Biomolecular Structure and Design Program.

Sen is a finalist in the Henne competition

Shila Sen was chosen as a finalist in the Chemistry & Biochemistry department's gradudate research competition, the Henne Competition. Congratulations, Shila!

Magliery presents at PepTalk

Prof. Magliery gave a presentation at PepTalk 2013 in Palm Springs on January 21. Magliery's talk, "Simplifying Protein Expression with Ligation-Free, Traceless and Tag-Switching Plasmids," was in the Protein Purification & Recovery session.

Mangla joins group for Biochem 1998H research experience

Shubham Mangla, a freshman Biochemistry major, joined the group for a Biochem 1998H research project for the spring semester.

Castle, Kumar join the group

Joe Castle and Anusha Kumar, both first-year Chemistry graduate students, joined the group at the beginning of spring semester. Joe received his B.S. from Muskingum University in Chemistry and Computer Science. Anusha is co-advised by Marcos Sotomayor, a new faculty member starting this fall. She earned her B.Tech. in Industrial Biotechnology from Anna University in Chennai, India. Welcome!

 

2012

Sen wins 2013 Presidential Fellowship

Shila Sen has received a Presidential Fellowship for 2013. The fellowship, which recognizes outstanding scholarship and research ability, is the highest scholarly award that the Graduate School gives to students. The fellowship pays for stipend, tuition and fees for a year to allow the student to devote his full attention to dissertation and research in the last year of graduate school. Congratulations, Shila!

Nie departs for CAS

Lihua Nie departed the group for Chemical Abstracts Service, here in Columbus, starting Nov. 23. Lihua's primary project was in the use of stop-codon scanning to trap protein interactions in living cells using unnatural amino acid mutagenesis. But in her 6.5 years as a postdoc in the group, she was involved in a broad range of the lab's science. Lihua is starting as an analyst for CAS. Congratulations, Lihua!

Lessig, Reyes win Undergraduate Research Scholarships

Kiersten Lessing and Chris Reyes both won Undergraduate Research Scholarships for the spring. These scholarships ar mostly for tuition, and are awarded for lab research proposals. Both students are juniors; Kiersten is a biochemistry major, and Chris is a chemistry major.

Magliery participates in the Rosetta Workship 2012

Prof. Magliery took part in Rosetta Workship 2012, Nov. 13-16, hosted by Jens Meiler's group at Vanderbilt University in Nashville.

Magliery presents seminar at Georgia State Chemistry

Prof. Magliery gave a seminar at Georgia State Chemistry in Atlanta on Oct. 26. Peng George Wang hosted on his 50th birthday. Happy birthday, George!

Long, Wahcnowsky start lab rotations

Nick Long and Christine Wanchnowsky started lab rotations for the second session of fall semester. Both are first-year OSBP students.

Magliery presents seminar for Ohio State Chemistry & Biochemistry

Prof. Magliery is presenting a seminar for the Department of Chemistry & Biochemistry at The Ohio State University at 11:30 am on Thursday, Sept. 27 in 111 Parks.

Magliery presents seminars at Colorado State, CU Boulder

Prof. Magliery is presenting seminars at Colorado State University and the University of Colorado, Boulder, on Setpember 13 and 14, respectively.

Magliery to give Faculty Lecture as part of 2012 Evans Lectures

Professor Magliery is giving a talk entiled, "Protein stability and topology: Surprises on the sequence landscape of a four-helix bundle," on Thursday, Sept. 6 at 1:30 pm in 2015 McPherson as part of the Faculty Lectures associated with the department's prestigous Evans Lecture. This year's Evans Lecturer is Chris Dobson from Cambridge University in the UK.

Magliery elected to Nominating Committee of the Protein Society

Professor Magliery was elected to the Nominating Committee of The Protein Society for a 3-year term from 2012-2015.

Grunkemeyer, Maugeri start lab rotations

Time Grunkemeyer, a first year OSBP graduate student, and Pearson Maugeri, a first year Biophysics graduate student, have started lab rotations for the first half of the fall semester.

Harsch to start postdoc at WPAFB

Recent Ph.D. graduate Christina Harch is starting a postdoctoral research position at Wright Patterson Air Force Base in Dayton this fall.

Johnston departs to start dental school

Sarah Johnston, who was a postbaccalaureate reseacher and then research assistant in the group since 2009, left the lab Aug. 15 to start dental school at Ohio State. Sarah was supported for two years by an ARRA Supplement to Prof. Magliery's NIH R01 grant from NIGMS. Sarah worked on a number of projects on Rop topology and on the X-ray crystal structures of several Rop variants. She also was an invaluable organizer of the lab. Good luck, Sarah!

Durani awarded postdoctoral fellowship from IIT Bombay Chemistry

Recent Ph.D. graduate Venuka Durani received a postdoctoral fellowship from IIT Bombay's Department of Chemistry to support her research there.

Magliery, Callahan, Sen present at Protein Society

Prof. Magliery gave a lecture at the 26th Annual Symposium of the Protein Society in San Diego, California, entitled, "Consensus and Correlation in Statistical Enzyme Engineering." The lecture was part of the Evolution symposium on Aug. 6. Nick Callahan and Shila Sen both presented posters at the conference.

5PON Conference is in Columbus July 15-18

Prof. Magliery was the chair of the organizing committee for the Fifth International Conference on Paraoxonases (5PON), hosted at Ohio State. The conference, held at The Blackwell, included over 120 participants from more than a dozen countries. Prof. Magliery co-organized the session on Structure and Biochemistry with Dan Tawfik, and he gave a lecture in that session. Kiran Doddapaneni, Christina Harsch, and David Mata all presented posters at the conference.

Pearson starts lab rotation

Stephen Pearson, an incoming first year graduate student in Biophysics, started a lab rotation for the last month of the summer term. Stephen earned his B.S. in Chemistry and Biochemistry from Kutztown University in Pennsylvania.

Doddapaneni wins travel award; Magliery, Doddapaneni present at CounterACT Symposium

Kiran Doddapaneni was selected for a travel award to the 6th Annual NIH CounterACT Network Research Symposium, June 26-28 in San Francisco, California. Kiran presented a poster, and Prof. Magliery presented a lecture with Douglas Cerasoli, Yacov Ashani and Shane Kasten.

Shete collaboration with Hadad group published in JPOC

A collaborattive project led by Siva Muthikrishnan in the Hadad lab and Vivkek Shete in the Magliery lab was accepted for publication in Journal of Physical Organic Chemistry. The study combined computational and experimental measurements of the interactions of pesticide metabolite analogs with paraoxonase-1. The study, entitled, "Mechanistic insights into the hydrolysis of organophosphorus compounds by paraoxonase-1: Exploring the limits of substrate tolerance in a promiscuous enzyme," was co-authored by Toby Sanan, Shubham Vyas, Shameema Oottikkal and Lauren Porter, all from the Hadad group.

Reinhart joins the lab

Elizabeth Reinhart, who earned her B.S. in Spanish with an emphasis in Pre-Medicine at Ohio State this spring, has joined the lab as a postbaccalaureate researcher. Liz is co-advised by Chuck Hitchcock in Pathology.

Alten, Lessig join the lab

E. David Alten and Kiersten Lessig, both rising junior undergraduate Biochemistry majors, have joined the Magliery lab starting this summer.

Mohan joins the lab

Sidharth Mohan, a first-year Biophysics student who did a lab rotation last summer, has joined the lab starting with summer term. Sid earned his B.Eng. in Biotechnology from the P.E.S. Institute of Technology in Bangalore, India.

Durani, Mata, Williams gradaute

Venuka Durani, David Mata and Danielle Williams received their diplomas at spring commencement. Venuka Durani is headed to IIT Bombay for postdoctoral research with Prof. Ruchi Anand. David Mata will be starting an ORISE postdoctoral fellowship at the U.S. Army Medical Research Institute of Chemical Defense in July. Danielle Williams will be starting graduate studies in Biochemistry at Yale University in the fall. Congratulations, all!

Castle starts summer research

Joe Castle, an incoming first-year graduate student in the Chemistry program, started a summer lab rotation. Joe received his B.S. in Chemistry and Computer Science from Muskingum University in Ohio.

Durani paper on pHLIC vectors accepted to Protein Expr Purif

A manuscript that is a combination of a review of modern E. coli protein expression vectors and a description of the pHLIC vectors described in the Magliery lab was accepted to Protein Expression and Purification. The paper, "Simplifying protein expression with ligation-free, traceless and tag-switching plasmids," was co-authored by Brandon Sullivan.

Callahan wins travel award, presents at CBSB12

Nick Callahan was selected for a travel award to present a poster at the 2012 From Computational Biophysics to Systems Biology conference in Knoxville, Tennessee, June 3-5.

Williams defends senior honors thesis

Danielle Williams defended her senior honors thesis, entitled, "Engineering Single-Chain Rop Variants and Combinatorial Libraries." Congratulations, Danielle!

Callahan presents at IGP Symposium

Nick Callahan was selected for an oral presentation, which he delivered at the 2012 Molecular Life Sciences IGP Symposium at the Ohio State Union on May 23.

Magliery speaks at Bioscience Review

Prof. Magliery presented a lecture on May 22 at the 2012 Bioscience Review in Hunt Valley, Maryland, hosted by the U.S. Army Medical Research Institute of Chemical Defense.

Callahan, Durani present posters at GLBIO

Nick Callahan and Venuka Durani both presented posters at the 2012 Great Lakes Bioinformatics Conference in Ann Arbor, Michigan.

Durani earns Ph.D.

Venuka Durani defended her Ph.D. dissertation in Chemistry, entitled, "The Cycle of Protein Engineering: Bioinformatics Design of Two Dimeric Proteins and Computational Design of a Small Globular Domain." Congratulations, Venuka!

Mata earns Ph.D.

David Mata defended his Ph.D. dissertation in Chemistry, entitled, "Understanding protein structure and function using rational design and unnatural amino acids." Congratulations, David!

Petrik joins the lab

Dr. Eva Petrik has joined the Magliery lab as a postdoctoral associate. Eva earned her M.Sc. in molecular biology from Eötvös Loránd University in Hungary. She earned her Ph.D. with Sheena Radford in Structural Molecular Biology at the University of Leeds in the UK. Eva will be working on improving high-throughput approaches to studying protein stability in the lab.

Williams presents posters at NMS Forum, Meek Lecture, Denman Forum

Danielle Williams presented her senior honors research project at the NMS Research Forum on April 20, at the Meek Lecture Poster Session on May 3, and at the Denman Undergraduate Research Forum on May 9. Danielle won an award for her presentation at the NMS Forum. Congratulations, Danielle!

Study on predicting protein stabilization accepted to JMB

A project led by graduate student Brandon Sullivan that was a longitudinal collaboration with several undergraduates was accepted to Journal of Molecular Biology. The study, "Stabilizing proteins from sequence statistics: The interplay of conservation and correlation in triosephosphate isomerase stability," was co-authored by graduate student Venuka Durani and undergraduates Tran Nguyen, Deepti Mathur, Sam Rojas, Miram Thomas and Trixy Syu. Tran and Miriam both earned senior honors theses for their work leading up to this publication.

Magliery presents seminar at UPenn Chemistry

Prof. Magliery presented a seminar in the Department of Chemistry at the University of Pennsylvania on April 12.

Reyes joins the lab

Christopher Reyes, an undergraduate Chemistry major, has joined the lab starting spring quarter.

Sarkar paper on PON1 soluility and 'humanization' accepted

A manuscript led by Chemistry graduate student Mohosin Sarkar, entitled, "Solubilization and humanization of paraoxonase-1," was accepted to the Journal of Lipids. It appears in a special issue on paraoxonases edited by Mickey Aviram and Alejandro Gugliucci. The paper was co-authored by graduate student Christina Harsch and undergraduates George Matic and Katy Hoffman, as well as our collaborators Joe Norris, Tamara Otto, David Lenz and Doug Cerasoli at USAMRICD.

Baldauff, Harsch, Ramasubramanian, Sullivan graduate

Rachel Baldauff, Christina Harsch, Brinda Ramasubramanian and Brandon Sullivan received their diplomas at Winter Commencement. Rachel left the lab in November 2011 and had a baby girl on Nov. 30. She is planning to be a stay-at-home mom for a while. Christina Harsch has been working as a postdoctoral researcher in the Magliery lab since Jan. 1, and will finish at the end of April. She is expecting her second child in May and plans to take some time at home this summer. Brinda Ramasubramanian worked as a postdoctoral researcher in the Magliery lab until February. She is staying at home with her daughter for the coming year, and is planning to apply for teaching jobs in India the year after. Brandon Sullivan has been a half-time instructor in Chemistry and half-time postdoctoral research in the Magliery lab since January 1. He is started a new project on antibody engineering for cancer imaging and detection in collaboration with Professors Edward Martin, Charles Hitchcock, Heather Allen and others at Ohio State. Congratulations to all!

Bowles goes to P&G Innovation Camp

David Bowles was selected for P&G's Innovation Camp in March.

Sen takes second place at Hayes Research Forum

Shila Sen won second place honors in the Math and Physical Sciences division for his oral presentation at the university-wide Hayes Research Forum. Congratulations, Shila!

Doddapaneni joins the lab

Dr. Kirian Doddapaneni joined the Magliery lab as a postdoctoral associate. Kiran earned his M.Sc. in Chemistry from Sri Krishna Deveraya University in India, and then earned an M.Tech. and Ph.D. from Jawaharlal Nehru Technological University, both in Biotechnology. Kiran was most recently a postdoctoral researcher with Prof. Justin Wu in the Department of Biochemistry at Ohio State. Kiran will be working on engineering and production of paraoxonase-1.

Magliery presents seminar at Wisconsin, Madison, Biochemistry

Prof. Magliery presented at seminar in the Biochemistry department of University of Wisconsin, Madison, on Jan. 30.

Callahan presents seminar at Muskingum Chemistry

Nick Callahan was invited to give a seminar presentation on Jan. 30 in the Department of Chemistry at Muskingum University.

Magliery, Hadad featured in hiVelocity

A story about Prof. Magliery and Prof. Christopher Hadad's NIH CounterACT Center grant renewal was featured on Jan. 26 in hiVelocity, an online magazine of Ohio business innovation.

Shete departs for India

Vivek Shete wrapped up his work on paraoxonase-1 in the Magliery Lab and returned to India to complete a set of interviews at biotech companies.

**Update Mar. 4** Vivek took a job as a scientist at Mahyco, one of the world's largest agribiotech companies. Congratulations, Vivek!

Cho, Li join the lab

Hyungseoph Jason Cho and Weiyi Li, both first year Chemistry graduate students, have joined the Magliery lab. Jason Earned is B.S. at the University of Suwon and his M.S. at Yonsei University, both in South Korea. (His M.S. advisor was Injae Shin, a postdoc in Peter Schultz's lab while Tom was a graduate student!) Weiyi Li earned his B.S. at the University of Massachusetts, Boston.

Hariharan starts lab rotation

Bala Hariharan, a first-year graduate student from the Biophysics program, is doing a lab rotation project in the winter quarter. Bala earned his M.Sc. from Anna University in Chennai, India.

 

2011

Magliery lab holiday and graduation party!

The Magliery Lab went to Moretti's of Arlington on Dec. 17 to celebrate our quarter of graduations and to kick off the holidays. Click the picture for a few more photos.

Sullivan earns Ph.D.

Brandon Sullivan defended his Ph.D. dissertation, entitled, "Engineering Proteins from Sequence Statistics: Identifying and Understanding the Roles of Conservation and Correlation in Triosephosphate Isomerase." Brandon was in the Ohio State Biochemistry Program.

Callahan advances to candidacy

Nick Callahan advanced to candidacy for the Ph.D. in the Biophysics program. Congratulations, Nick!

Harsch earns Ph.D.

Christina Keventzidis Harsch defended her Ph.D. dissertation in Chemistry, entitled, "Mutagenic Studies of Substrate Specificity and Stability of Paraoxonase-1." Congratulations, Christina!

Ramasubramanian earns Ph.D.

Brinda Ramasubramanian defended her Ph.D. dissertation in Chemistry, entitled, "Combinatorial Approaches to Study Protein Stability: Design and Application of Cell-Based Screens to Engineer Tumor Suppressor Proteins." Congratulations, Brinda!

Magliery presents seminars at UCSF, Berkeley

Prof. Magliery will present seminars for the Q3 program at UCSF on Nov. 28, and for the Chemistry department at Berkeley on Nov. 29.

Baldauff earns M.S.

Rachel Baldauff successfully defended her Master's thesis in Chemistry, entitled, "Interaction of Recombinant Paraoxonase-1 with Reconstituted High-Density Lipoproteins." Rachel was a co-advisee of Dr. Magliery and Dr. Terry Gustafson. Congratulations, Rachel!

Center of Excellence renewal highlighted by OSU, OSC

The renewal of the NIH Center of Excellence grant, led at Ohio State by Prof. Magliery and Prof. Christoher Hadad, was highlighted in OSU Research News, OSU Today, the College of Arts & Sciences, and by the Ohio Supercomputer Center.

OSU Research NewsOSU TodayArts & SciencesOhio Supercomputer Center

Magliery presents seminar at Indiana Chemistry

Prof. Magliery will present a seminar at the Indiana University Department of Chemistry on Oct. 14.

Magliery featured in CDD User Spotlight

Magliery is the featured investigator on the CDD User Spotlight, a web feature of Collaborative Drug Discovery. The Magliery lab uses the CDD platform to organize and analyze biochemical data.

Bennett, Cho, Li begin informal rotations

Three first-year Chemistry graduate students started informal rotations projects for the fall: Raffeal Bennett, Hyungseoph (Jason) Cho, and Xiankun Li.

Renewal of NIH Center of Excellence biodefense grant is funded

An NIH U54 Center of Excellence grant led by Douglas Cerasoli at the U.S. Army Medical Research Institute of Chemical Defense and Prof. Magliery was funded. The proposal, "Center for Catalytic Bioscavenger Medical Defense Research II: Discovery, Formulation and Preclinical Evaluation," was awarded $7.5M over three years. Partners on the project include Christopher Hadad at OSU, P. George Wang, who recently moved to Georgia State as a Georgia Eminent Scholar, and a group led by Dan Tawfik and Joel Sussman at The Weizmann Institute in Israel. The grant is a renewal of a five-year effort led by David Lenz, who recently retired from USAMRICD, and Cerasoli, bringing the total funding for the project to $22M over 8 years. The project is funded through the Countermeasures Against Chemical Threats (CounterACT) program of the National Institute of Neurological Disorders and Stroke (NINDS).

Magliery joins Microbiology graduate program

Prof. Magliery is now a member of the Microbiology graduate program. Microbiology students who are interested in joining the group should contact Dr. Magliery directly.

Magliery presents seminars at ASU Biodesign and Arizona Chemistry & Biochemistry

Prof. Magliery presented seminars at the Biodesign Institute at Arizona State University on Sept. 8 and at the Chemistry and Biochemistry department of the University of Arizona on Sept. 9.

Sen advances to candidacy

Shila Sen, a third year Chemistry graduate student, advanced to candidacy at the end of the summer. Congratulations, Shila!

Bowles receives CBIP fellowship

First-year OSBP graduate student David Bowles, who joined the lab at the beginning of summer, was awarded a Chemistry-Biology Interface Training Program fellowship for the 2011-2012 school year. The NIH CBI training grant was recently renewed, led by Prof. Dehua Pei. David is the third CBI fellow in the Magliery lab (after Jason Lavinder and Brandon Sullivan).

Magliery, Durani present at fall ACS national meeting in Denver

Venuka_ACS_2011Prof. Magliery gave an oral presentation in the Breakthroughs in Biological Chemistry session of the fall national meeting of the American Chemical Society in Denver, held Aug. 28-Sept. 1. Venuka Durani also presented a poster in the Current Topics in Biological Chemistry session.

Schoenfeldt finishes postbac research

Ted Schoenfeldt finished his post-baccalaureate research in the Magliery lab at the end of the summer. Ted is planning to work and volunteer in healthcare while he applies to medical school this year.

Magliery selected as chair of organizing committee for Fifth International Conference on Paraoxonases

The Scientific Committee of the International Conferences on Paraoxonases selected Prof. Magliery as the chair of the local organizing committee for the fifth meeting of the conference. The conference will be held July 15-18, 2012, at The Blackwell on the campus of The Ohio State University in Columbus, Ohio. Doug Cerasoli (USAMRICD), Drago Dragonov (WIL Research Labs), Clem Furlong (U. Washington Seattle), Christopher Hadad (Ohio State), Stan Hazen (Cleveland Clinic), David Lenz (USAMRICD, retired) and Sampath Parthasarathy (Ohio State Medicine) make up the rest of the committee. More details will be posted here in November.

Sullivan paper on protein design from sequence statistics accepted to JMB

Brandon Sullivan's paper, "Triosephosphate Isomerase by Consensus Design: Dramatic Differences in Physical Properties and Activity of Related Variants," was accepted to the Journal of Molecular Biology. The paper describes the design of a sophisticated enzyme from sequence statistics and explores the roles of correlated residues in the differences among similar variants. Brandon is an OSBP graduate student, and his co-author Venuka Durani is a Chemistry graduate student.

Magliery, Sullivan present posters at 25th Anniversary Symposium of the Protein Society

Prof. Magliery and Brandon Sullivan both presented posters at the 25th Anniversary Symposium of the Protein Society in Boston, July 23-27. Sullivan received the Ray Travel Award and a travel award from The Protein Society to attend.

Mohan starts summer rotation

Sidharth Mohan, a first-year graduate student in the Biophysics program, has started a rotation project for the summer quarter.

Magliery presents at CounterACT Symposium; Mata wins travel award

Prof. Magliery presented at the 5th Annual CounterACT Network Research Symposium in Washington, D.C on June 21. Christina Harsch, David Mata and Vivek Shete presented posters at the meeting. David won a travel award from CounterACT to attend. Congratulations, David!

Sen presents poster at High-Throughput Chemistry and Chemical Biology Gordon conference

Shila Sen presented a poster at the Gorodon Research Conference on High-Throughput Chemistry and Chemical Biology, June 19-24 at Colby Sawyer College in New London, New Hampshire. Shila also participated in the associated Gordon Research Seminar June 18-19.

Hadad, Hayes, Rojas, Schoenfeldt, Weppler, and Williams do summer research

Six students will do undergraduate or post-baccalaureate research in the Magliery lab for the summer. Amanda Hadad is a rising sophomore Biochemistry major. Mary Lynne Hayes just graduated from Alabama A&M in Chemistry. Samantha Rojas, a rising senior at Kenyon College in Chemistry, returns for a second summer. Ted Schoenfeldt, who has been doing post-baccalaureate research in the lab since his graduation at the end of winter quarter, was a Chemistry major. Jendy Weppler, a rising junior, is a Chemistry and Molecular Biology major at Muskingum University, where she is a student of Prof. Deepa Perera. Dr. Perera was a visiting scholar in the Magliery lab in the first half of 2010. Danielle Williams, a rising senior and Chemistry summer fellowship recipient, is continuing her honors thesis research.

Bowles joins the lab

David Bowles, a first-year OSBP student who did a rotation project in the fall of 2010, joined the lab. David will be working on tumor suppressor protein stability. He is a graduate of University of Cincinnati.

Hoffman defends honors thesis, graduates

Katy Hoffman defended her Senior Honors thesis on May 20, and she graduated on June 20 with a double major in Chemistry and Pharmaceutical Sciences. Her thesis is entitled, "Enhancing solubility, stability and catalytic properties of human paraoxonase-1 for use as a therapeutic agent in organophosphorus poisoning." Congratulations, Katy!

Magliery presents at Bioorganic Chemistry Gordon Conference

Prof. Magliery was invited to give a short talk at the Gordon Conference in Bioorganic Chemistry. The conference was June 12-17 at the Proctor Academy in Andover, New Hampshire.

Panneerselvam joins the lab

Nishanthi Panneerselvam, who did a rotation project in spring, joined the lab at the beginning of summer quarter. Nishanthi, a first-year Biophysics graduate student from Anna University in India, will be working on high-throughput characterization of protein properties.

Williams receives Chemistry summer research fellowship

Danielle Williams received a summer research fellowship from the Chemistry department, covering half of her summer stipend. Congratulations, Danielle!

Magliery wins Siddens Award for Distinguished Faculty Advising

Prof. Magliery received the James M. Siddens Award for Distinguished Faculty Advising. The award is "to recognize those faculty who exemplify the best in graduate student advising at Ohio State. The only award of its kind on campus, this award is given annually each spring to one member of the graduate faculty." The award is given by the Council of Graduate Students.

Hoffman, Schoenfeldt and Williams present at undergraduate research forums

Katy Hoffman, Ted Schoenfeldt and Danielle Williams presented posters at the NMS Undergraduate Research symposium on April 29, the Meek Lecture on May 5, and the university-wide Denman Undergraduate Research Forum on May 11. Ted received one of the top poster awards for his presentation at the NMS forum.

Sullivan wins Ray, Protein Society Travel Awards

Brandon Sullivan won two separate travel awards to attend The 25th Anniversary Symposium of the Protein Society. He received the Ray Travel award, which is administered by the Council of Graduate Students. He also received a travel award from The Protein Society.

Magliery presents seminar at UIUC Chemistry

Prof. Magliery presented a seminar in Chemistry at the University of Illinois, Urbana-Champaign, on May 10.

Williams wins Thomas, Booth scholarships

Danielle Williams won two scholarships from the Chemistry department, each for $3,000. She received awards from the Gary Booth Scholarship Fund in Chemistry and The Bertrand Thomas Memorial Fund. Congratulations, Danielle!

Magliery presents seminar at University of Akron Chemistry

Prof. Magliery presented a seminar the the University of Akron Department of Chemistry on Apr. 27.

Panneerselvam starts rotation

Nishanthi Panneerselvam, a first yeat Biophysics student, started a rotation project for spring quarter. Nishanthi is a graduate of Anna University in India.

Magliery presents seminars at Columbia, Princeton Chemistry

Prof. Magliery presented seminars at Columbia University Chemistry on Mar. 23 and Princeton University Chemistry on Mar. 24.

Review on high-throughput and statistical methods in protein stability is accepted to Curr Opin Chem Biol

Prof. Magliery's review, "Protein stability by number: high-throughput and statistical approaches to one of protein science's most difficult problems," was accepted to Current Opinion in Chemical Biology. The review was written with former graduate student Jason Lavinder and current graduate student Brandon Sullivan.

Schoenfeldt graduates

Ted Schoenfeldt, who joined the group in the fall, graduated with a Chemistry major at the end of winter quarter. Congratulations, Ted! Ted will continue working in the Magliery lab through the spring quarter.

Magliery presents seminar at Purdue Chemistry

Prof. Magliery presented a seminar in the Chemistry department at Purdue University on Feb. 22.

Sullivan is a finalist in the university-wide Hayes Graduate Research Forum

Brandon Sullivan was a finalist in the 25th annual university-wide Hayes Graduate Research Forum, sponsored by the Council of Graduate Students. Brandon won second place in the Biological Sciences for his oral presentation. Congratulations, Brandon!

Sullivan wins MAGS Excellence in Teaching Award

Brandon Sullivan was chosen as the doctoral award winner for the Midwest Association of Graduate Schools Excellence in Teaching Award. Brandon spoke at the awards luncheon on Mar. 31 in Milwaukee. Congratulations, Brandon!

Sullivan is a finalist in the Chemistry Henne Graduate Research Competition

Brandon Sullivan was selected as one of three finalists for the department's Henne research competition. Brandon gave an oral presentation and took second place honors. Congratulations, Brandon!

Magliery presents seminars at Caltech, UCLA Chemistry

Professor Magliery presented seminars at Caltech Chemistry on Jan. 27 and at UCLA Chemistry on Jan. 28.

Nie paper on stop-codon scanning mutagenesis accepted to JACS

Lihua Nie's paper, "Synthetic approach to stop-codon scanning mutagenesis," was accepted to the Journal of the American Chemical Society. The paper describes a method of scanning an amber stop codon through a gene, for suppression with natural or unnatural amino acids, with complete synthetic control. Lihua is a postdoctoral researcher. Her co-authors were Jason Lavinder, now a postdoc at UT Austin, Mohosin Sarkar, now a postdoc at Scripps Florida, and Kim Stephany, who completed work on this manuscript as an NSF REU summer fellow.

Yu begins rotation

Ryan Yu, a first-year graduate student in OSBP, is doing a rotation project in the Magliery lab for the Winter quarter. Ryan is a graduate University of California, Berkeley.

 

2010

Williams wins Undergraduate Research Scholarship

Danielle Williams was awarded a $2,500 scholarship from the College of Arts and Sciences Honors Committee in recognition of her excellent research proposal. The Undergraduate Research Scholarship is awarded for the 2011-12 academic year. Congratulations, Danielle!

Sen nominated for HHMI fellowship

Shila Sen was selected as one of ten nominees for the Howard Hughes Medical Institute (HHMI) International Student Research Fellowship. The university was one of a select number of institutions invited to nominate up to ten outstanding international students for the fellowship. Congratulations on the honor, Shila!

Sullivan wins Presidential Fellowship for 2011

Brandon Sullivan received a Presidential Fellowship from the Graduate School for the 2011 calendar year. The fellowship, which recognizes outstanding scholarship and research ability, is the highest scholarly award that the Graduate School gives to students. The fellowship pays for stipend, tuition and fees for a year to allow the student to devote his full attention to dissertation and research in the last year of graduate school. Congratulations, Brandon!

Magliery presents seminar at The Scripps Research Institute

Professor Magliery will present a seminar at The Scripps Research Institute on Nov. 16.

Magliery presents seminar at University of Delaware Chemistry and Biochemistry

Professor Magliery will present a seminar in Chemistry and Biochemistry at the University of Delaware on Nov. 8.

Magliery presents seminar at Georgia Tech Chemistry

Professor Magliery will present a seminar in Chemistry at Georgia Tech on Nov. 4.

Sullivan wins Graduate School Vetter award

Brandon Sullivan received the Graduate School's Louise B. Vetter Award, sponsored by the Honor Society of Phi Kappa Phi. The $1,500 scholarship recognizes academic achievement and commitment to service. Congratulations, Brandon!

Magliery presents seminars at MIT Chemistry and Harvard BCMP

Professor Magliery presented seminars in the Chemistry department at MIT on Sept. 27 and in the Biological Chemistry and Molecular Pharmacology department at Harvard Medical School on Sept. 28.

Haverick, Patel begin informal rotations

Mark Haverick and Krishna Patel, both first year students in the Chemistry graduate program, began informal rotations in the Magliery lab at the beginning of the fall quarter.

Bowles begins OSBP rotation in Magliery lab

David Bowles, as first year graduate student in the Ohio State Biochemistry Program, started a 10 week rotation in the Magliery lab for this autumn. David earned a B.S. in Chemistry with a Biochemistry concentration at the University of Cincinnati.

Schoenfeldt joins the lab

Ted Schoenfeldt, a senior undergraduate student in Chemistry, has joined the lab.

Johnston begins Master's program in Anatomy

Sarah Johnston started a Master's program in Anatomy at the OSU Medical School. She is continuing on as a research assistant in the group during her M.S. program, specializing in protein crystallization and aiding in the running of the lab.

Magliery speaks at International Paraoxonases Conference in La Pineda, Spain

Professor Magliery spoke at the 4th International Conference on Paraoxonases in La Pineda, Spain, which is an hour south of Barcelona on the Meridterranean coast. His talk was entitled, "Protein engineering to improve the physical properties and elucidate substrate specificity determinants of paraoxonase-1." The conference was principally organized by Jordi Camps, Michael Mackness and Bharti Mackness from Centre de Recerca Biomedica.

Murali joins the lab as research assistant

Srividya Murali has joined the Magliery lab as a research assistant who will specialize in the large-scale production and purification of proteins. Vidya earned a B.Sc. and M.Sc. in Botany from the University of Chennai in India. She has worked at OSU Medical School and Applied Biomolecular Technologies, among other places, as a researcher in molecular biology.

Magliery presents seminar at Merrimack Pharmaceuticals

Professor Magliery presented a seminar at Merrimack Pharmaceuticals in Cambridge, Massachusetts, on Aug. 25.

Magliery organizes session, speaks at ACS National Meeting in Boston

ACS_Boston_2010Professor Magliery organized a session in the Biological Division of the ACS at the 2010 Fall National Meeting. The session on Aug. 24 was entitled, "Design, Discovery, and Directed Evolution of Enzyme Activities," and featured Amy Keating from MIT, Patsy Babbitt from UCSF, Yi Lu from UIUC and Magliery. Magliery's talk was entitled, "Engineering proteins for stability and function with statistical and high-throughput approaches."

Mata, Ramasubramanian win travel awards to Fall ACS Meeting; Harsch, Nie, Shete, and Sullivan also present

David Mata and Brinda Ramasubramanian received travel awards from the ACS Division of Biological Chemistry to attend the Fall National Meeting in Boston. Congratulations, David and Brinda! Both presented posters at the meeting, as did Christina Harsch, Lihua Nie, Vivek Shete and Brandon Sullivan.

Nguyen completes Master's degree, begins Pharm.D. program at University of Maryland

Chau Nguyen successfully defended her Master's thesis in Chemisty entitled, "Protein Engineering Surface Residues of the Four-helix Bundle Protein Rop: Evaluating the Relationship of Sequence-Stability through High-Throughput Approaches." Chau is starting in the Pharm.D. program at the University of Maryland this fall. Congratulations, Chau!

Humes departs for Master's program in Biomedical Sciences at Colorado State

Andrew Humes started a Master's program in the Department of Biomedical Sciences at Colorado State University in Fort Collins, Colorado. Humes had been a research assistant specializing in large-scale protein production since last fall.

Stephany returns for summer research, starts Ph.D. program at Ohio State

Kim Stephany, a 2009 NSF REU Fellow in the Magliery lab, returned to the lab in the summer of 2010 to do a rotation in the lab. Kim will be starting in the Chemistry graduate program this fall.

Cooper, Rojas join the lab for the summer

Grace Cooper and Samantha Rojas joined the lab to do summer research with the Magliery group. Grace is a rising senior Chemistry major at Carleton College in Northfield, Minnesota. Sam is a rising junior Chemistry major at Kenyon College in Gambier, Ohio.

Callahan joins the lab

Nicholas Collahan, a first year graduate student in the Biophysics program, joined the lab. Nick will be co-advised by Will Ray at Nationwide Children's Hosptial Research Institute. Nick earned his B.A. in Biochemistry and English from Case Western Reserve University in Cleveland.

Magliery speaks at CounterACT; Harsch and Mata present posters

Professor Magliery spoke with David Lenz and Douglas Cerasoli at the 4th Annual CounterACT Network Research Symposium, which was held in San Francisco June 22-24. In addition, David Mata and Christina Harsch received CounterACT travel awards (see below) and presented posters at the meeting.

Mata advances to candidacy

David Mata, a graduate student in the Chemistry program, advanced to candidacy for the Ph.D. Congratulations, David!

Magliery, Nie speak at CERMACS in Dayton

Professor Magliery and Lihua Nie gave oral presentations at the June 16-19, 2010, Central Regional Meeting of the American Chemical Society, in Dayton, Ohio. Magliery's talk was entitled, "Combinatorial Design of a Four-Helix Bundle Protein Using High-Throughput Thermal Scanning," and Nie's talk was entitled, "Convenient Stop Codon Scanning Mutagenesis Method for Alanine and Unnatural Amino Acid Scanning."

Magliery organizes session, speaks at OCCBIO; Durani, Sullivan present posters

Professor Magliery organized a session on Structural Bioinformatics at the 2010 Ohio Collaborative Conference on Bioinformatics, hosted at the Ohio Union. The session speakers were John Hawes from Miami University, Aleksey Porollo from University of Cincinnati, Helen Piontkivska from Kent State University, Magliery, and Mark Gerstein from Yale. In addition, Venuka Durani and Brandon Sullivan presented posters at the conference, which was held June 15-17.

Bharwani, Nguyen graduate

Natasha Bharwani and Tran Nguyen graduted in the spring quarter. Bharwani completed her B.S. in Microbiology, and is beginning a research position with Shohei Koide at the University of Chicago this summer. Nguyen completed her B.S. in Molecular Genetics with research distinction in Biochemistry, and is preparing to apply for graduate school in the fall. Congratulations, Natasha and Tran!

Durani speaks at CBSB10

Venuka Durani won a travel award and gave a presentation at the 2010 From Computational Biophysics to Systems Biology meeting in Traverse City, Michigan, June 6-8. Her talk was entitled, "Correlated networks within proteins: What do they mean?" Congratulations, Venuka!

Magliery speaks at Bioscience Review

Professor Magliery presented a talk entitled, "Engineering the activity and physical properties of paraoxonase-1 as an organophosphorus nerve agent countermeasure," at the Bioscience Review 2010 meeting hosted by the U.S. Army Medical Research Institute of Chemical Defense in Hunt Valley, Mayland on May 24. The session on Pretreatments was chaired by Douglas Cerasoli and Yaacov Ashani.

Nguyen completes senior honors thesis

Tran Nguyen, a senior Molecular Genetics major who will graduate at the end of spring quarter, successfulyl defended her Senior Honors thesis in Biochemistry for research distinction. Her thesis was entitled, "Statistical Analysis to Stabilize Proteins." Congratulations, Tran!

Magliery lab members participate in Race for the Cure

Venuka Durani, Bev Goudy, Christina Harsch, Katy Hoffman, Sarah Johnston, David Mata, Chau Nguyen, Linua Nie, Deepa Perera, Brinda Ramasubramanian, Shila Sen, Luke Smith and Danielle Williams participated in the 2010 Komen Race for the Cure on May 15 as the Raging Cloners. The team raised $350 for breast cancer research. Pictured: Johnston, Nguyen, Smith, Mata, Hoffman, Nie, Sen and Durani.

Undergraduates present posters at BMAPS, Denman forums

Natasha Bharwani, Katy Hoffman, Tran Nguyen, Luke Smith and Danielle Williams presented posters at the 2010 BMAPS college undergraduate research forum and the 2010 Denman Undergraduate Research Forum. Tran received first prize in the Biological Sciences for her poster, " Statistical Analysis to Stabilize Triosephosphate Isomerase." Congratulations, Tran! Pictured: Hoffman, Bharwani, Smith, Williams and Nguyen at the BMAPS forum.

Hoffman wins Summers Research Scholarship from University Honors & Scholars

Katy Hoffman was awarded a Summer Research Scholarship from the University Honors and Scholars office. The scholarship provides a stipen to support 10 weeks of research in the summer. Congratulations, Katy!

Nguyen wins Dean's Undergraduate Research Fund award

Tran Nguyen received a Dean's Undergraduate Research Fund award for Biological Sciences students. Tran is a senior honors student in the Magliery lab and a Molecular Genetics major. Congratulations, Tran!

Magliery speaks at ASBMB National Meeting in Anaheim, CA

Professor Magliery gave a short talk at the 2010 ASBMB meeting entitled, "Combinatorial design of a four-helix bundle protein using high-throughput thermal scanning." The talk was in the Chemical Biology: Evolution, Engineering and Design session on Apr. 28 chaired by Adrian Whitty, and it was part of a larger theme of Chemical Biology and Drug Discovery organized by Whitty and Peter Tonge.

Sullivan wins Graduate Associate Teaching Award

Dean Osmer and others from the Graduate School surprised Brandon Sullivan during group meeting on Apr. 16 with the presentation of a 2010 Graduate Associate Teaching Award. This is Ohio State's highest honor to recognize exceptional teaching by graduate students. Brandon was one of ten 2010 awardees. Congratulations, Brandon!

Magliery presents seminar at U. Washington, Seattle

Professor Magliery will present a seminar in Chemistry at the University of Washington, Seattle, on April 14.

Harsch, Mata win travel awards to CounterACT 2010

Chemistry graduate students Christina Harsch and David Mata both received travel awards to the 4th Annual CounterACT Network Research Symposium, which will be held in San Francisco, June 22-24, 2010.

Baldauff joins the lab

Rachel Baldauff, a Chemistry graduate student in the analytical division, has joined the Magliery group. Rachel is co-advised by Prof. Magliery and Prof. Terry Gustafson. She is a 2008 chemistry graduate of Rose-Hulman in Terre Haute, Indiana.

Magliery presents seminar at U. Michigan

Professor Magliery presented a seminar in Molecular, Cellular and Developmental Biology at the University of Michigan, Ann Arbor, on March 5.

Smith completes Senior Honors thesis

Luke Smith, a Microbiology major who will graduate at the end of Winter quarter, successfully defended his Senior Honors thesis in Biochemistry for research distinction. His thesis is entitled, "SICLOPPS-derived Libraries as a Means to Rescue Complex Formation Inhibited by Cancer Mutations." Congratulations, Luke!

Harsch wins Swenton award for teaching

Chemistry graduate student Christina Keventzidis Harsch was one of two recipients of the 2010 John S. Swenton Award for Outstanding Teaching by Graduate Students. Her award citation reads, "Mrs. Harsch has served as a GTA for 10 quarters in a variety of courses, ranging from undergraduate general and organic chemistry to graduate-level courses under the supervision of six different lead instructors. Evaluation comments include: 'went above and beyond to help and instruct her students; motivated them to work hard, excellent teacher'; 'always well prepared, good communication'; 'great TA, mentor for the students'; and 'enthusiastic and well-liked by her students.'" Congratulations, Christina!

Sarkar departs for postdoc with Tom Kodadek at Scripps Florida

Mohosin Sarkar departed to begin a postdoctoral position with Tom Kodadek in Chemistry at The Scripps Research Institute in Jupiter, Florida. Sarkar had defended his Chemistry Ph.D. dissertation in December and was a postdoctoral researcher in the Magliery lab until now. Good luck, Mohosin!

Magliery speaks at MBI workshop on Synthetic Biology

Professor Magliery presented a talk at the workshop on Synthetic Biology at the Mathematical Biosciences Institute at Ohio State on Jan. 28.

Goudy joins Magliery group as Chemistry rotation student

Beverly Goudy began a research rotation in the Magliery lab for the winter of 2010. Bev received her B.S. in Chemistry in 2008 from Ashland University, where she did research with Perry Corbin.

Bharwani, Williams receive BioSci Dean's Undergraduate Research Fund Awards

Natasha Bharwani and Danielle Williams both received Dean's Undergraduate Research Fund awards for Biological Sciences students. Natasha is a senior Microbiology major who expects to graduate this spring, and Danielle is a sophomore Microbiology major who is planning to do research in the Magliery lab this summer. Congratulations, Danielle and Natasha!

Perera joins as Visiting Scholar

Deepa Perera, Professor and Chair of Chemistry at Muskingum University in Ohio has joined the Magliery lab as a Visiting Scholar for the first half of 2010. Deepa will be working on experimental and computational aspects of protein design from sequence statistics.

 

2009

Hari manuscript on cysteine-free Rop published in Protein Science

The manuscript, "Cysteine-free Rop: A four-helix bundle core mutant has wild-type stability and structure but dramatically different unfolding kinetics," was accepted to Protein Science. The first two authors, Sanjay Hari and Chang Byeon, were undergraduate researchers from 2006-2008 and 2005-2006, respectively. The third author is OSBP Ph.D. Jason Lavinder. Hari is now a graduate student in Chemistry at University of Washington, Seattle, and Byeon is studying at University of Pittsburgh, Greenburg.

Nguyen, Smith win Arts & Sciences Undergraduate Research Scholarships

Tran Nguyen and Luke Smith, undergraduate majors in Molecular Genetics and Microbiology, respectively, were both recipients of Undergraduate Research Scholarships from the Arts and Sciences College for their work in the Magliery lab. The scholarships go toward their tuition and fees in Winter and Spring. Congratulations, Tran and Luke!

Hoffman wins College of Pharmacy Undergraduate Research Scholarship

Kathryn Hoffman, an undergraduate major in Chemistry and Pharmaceutical Sciences, received an Undergraduate Research Scholarship from the College of Pharmacy for her work in the Magliery lab. The scholarship helps cover her tuition and fees in Winter and Spring. Congratulations, Katy!

Sarkar earns Ph.D. for work with split GFP reassembly, paraoxonase engineering

Mohosin Sarkar earned the second Ph.D. in the Magliery lab, and the first in Chemistry, for his thesis entitled, "Engineering Proteins with GFP: Study of Protein-Protein Interactions In Vivo, Protein Expression and Solubility." Mohosin earned his B.Sc. in Applied Chemistry from the University of Dhaka in Bangladesh in 1996. He earned an M.S. in Chemistry from Kent State and then started his doctoral studies at Ohio State in 2004, first with Sean Taylor and then with the Magliery lab starting in 2006. Mohosin has published in Molecular BioSystems and Protein Expression and Purification, and he is preparing three more manuscripts from his thesis. Congratulations, Mohosin!

Magliery presents seminars at UMass Amherst and UMass Worcester

Professor Magliery will present seminars for the Department of Chemistry at University of Massachusetts, Amherst, on Dec. 10 and for the Department of Biochemistry and Molecular Pharmacology at University of Massachusetts, Worcester, on Dec. 11.

Nguyen, Smith win Dean's Undergraduate Research Award

Tran Nguyen, a senior Molecular Genetics major, and Luke Smith, a senior Microbiology major, both won Autumn 2009 Dean's Undergraduate Research Awards from the College of Biological Sciences. Congratulations Tran and Luke!

Humes starts as research assistant

Andrew Humes has joined the Magliery lab as a research assistant who will specialize in the large-scale production and purification of variants of paraoxonase-1. Humes is a 2008 graduate of Ohio State with a B.S. in Plant Cellular and Molecular Biology and a B.A. in Anthropology. He was a microbiologist at Pharmaforce before this.

Barna begins CBIP rotation

Christopher Barna started a CBIP rotation at the beginning of November. Chris is a 2009 graduate of Penn State University and is currently a first-year OSBP student.

Magliery speaks at West Virginia State University

Professor Magliery presented a seminar for the Department of Chemistry at West Virginia State University in Institute on Oct. 27.

Lavinder departs for postdoc with Georgiou at UT Austin

Jason Lavinder departed to begin a postdoctoral research position with George Georgiou at the University of Texas, Austin, in Chemical Engineering. Jason earned his Ph.D. (OSBP) from the Magliery lab in the spring of 2009 and has worked as a postdoc with us since then. Good luck, Jason!

Magliery presents seminar at Biogen Idec

Professor Magliery presented a seminar at the Cambridge, MA, biotech company Biogen Idec on Oct. 14.

Harsch collaboration with USAMRICD published in Biochemistry

The first paper from the Magliery group's collaboration with the U.S. Army Medical Research Institute for Chemical Defense was published in Biochemistry. The work, led by Tammy Otto at USAMRICD and Christina Harsch at Ohio State, was entitled, "Dramatic difference in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes." See the Publications page or doi:10.1021/bi901161b for the full article.

Chakravarthy begins OSBP rotation

Harshini Chakravarthy is doing a research rotation with the Magliery lab in Autumn 2009. Harshini earned her B.Sc. from Mumbai University in 2005 and her M.Sc. from M.S. University of Baroda in 2007, both in microbiology. She is a first-year OSBP graduate student.

Williams joins the lab

Danielle Williams joined the lab for the Autumn 2009 quarter. Danielle is a sophomore Microbiology major.

Nadaud, Sarkar paper published in Protein Expr. Purif.

Our collaboration with Christopher Jaroniec's group to produce uniformly isotopically labeled peptides for solid-state NMR by proteolysis from an expressed fusion protein was published in Protein Expression and Purification. The work was led by Philippe Nadaud in the Jaroniec group and Mohosin Sarkar. See the Publications page or doi:10.1016/j.pep.2009.09.017 for the full article.

Magliery presents seminar for U.T., Austin, Biophysics

Professor Magliery presented a seminar the University of Texas, Austin, in the Biophysics program on Sept. 21.

NIH ARRA Supplement for fluorimeter, research assistant funded

An American Recovery and Reinvestment Act supplement to Professor Magliery's NIH R01 grant on Combinatorial Biophysics was funded. The supplement pays for a fluorimeter and the salary of a full-time research assistant for two years. Sarah Johnston, currently a 3/4-time research assistant in the lab, will fill this position.

Magliery speaks at Proteins Gordon conference

Prof. Magliery was invited to give a short talk at the 2009 Gordon Research Conference on Proteins, at the Holderness School in Plymouth, NH, June 21-26.

Stephany joins lab for summer as REU fellow

Kim Stephany, a rising senior at Marian University in Fond du Lac, Wisc., has joined the Magliery lab for the summer as part of the Department of Chemistry's NSF REU program. Stephany is a Chemistry and Biology major.

Hoffman, Smith join the lab

Kathryn Hoffman and Luke Smith joined the Magliery lab starting this summer. Smith is a rising senior majoring in Microbiology, and he was awarded a 2009 Mayers Research Internship from the College of Biological Sciences for his work this summer. Hoffman is a rising junior double majoring in Chemistry and Pharmaceutical Sciences.

Lavinder collaboration with Deniz, Onuchic published in PNAS

A collaboration between the Magliery lab and the labs of Ashok Deniz at The Scripps Research Institute and Jose Onuchic at University of California, San Diego, resulted in a paper in the Proceedings of the National Academy of Sciences, U.S.A., entitled, "Direct single-molecule observation of a protein living in two opposed native structures." The work was lead in the Magliery lab by Jason Lavinder.

UPDATE. A News & Views piece about this article from TSRI was featured on the NIGMS website ("Protein Wavers Between Two Forms").

Lavinder earns first Magliery lab Ph.D.

Jason Lavinder received the fist Ph.D. from the Magliery group for his dissertation entitled, "Analyzing the Sequence-Stability Landscape of the Four-Helix Bundle Protein Rop: Developing High-Throughput Approaches for Combinatorial Biophysics and Protein Engineering." Jason started at Ohio State in 2002 after earning his B.S. in Biology from Wright State. He moved from Sean Talyor's lab in 2006. Jason has published in JACS and PNAS and is preparing four more papers for publication. Jason was a CBIP Fellow from 2004-2006 and a pre-doctoral fellow of the American Heart Association from 2007-2009. Congratulations, Jason!

Callahan begins Biophysics rotation

Nicholas Callahan, who will be starting in the Biophysics graduate program this fall, began a research rotation for the summer in the Magliery lab. Nick was a double major in Biochemistry and English at Case Western Reserve University in Cleveland.

Sullivan advances to candidacy

Brandon Sullivan advanced to candidacy for a Ph.D. in the Ohio State Biochemistry Program. Congratulations, Brandon!

Matic, Porter complete Senior Honors theses

George Matic and Ely Porter both completed Senior Honors theses this quarter, and will graduate with research distinction for Spring, 2009. Commencement is June 14. George is a Medical Technology major, and his thesis is entitled, "Rational design and directed evolution of human paraoxonase I (huPON1) for increased solubility and stability in E. coli." Ely is a Biology major earning distinction in Biochemistry, with a thesis entitled, "Tumor suppressor p53: Mutagenesis and loop swapping to improve stability." Congratulations, Ely and George!

Magliery presents Pharmacology seminar on May 14

Prof. Magliery will present a seminar for the Ohio State Pharmacology department on May 14 at noon in 1175 Graves Hall.

Nguyen wins award at 2009 Denman Forum

Tran Nguyen took third place honors in Biological Sciences at the 2009 Denman Undergraduate Research Forum. Congratulations, Tran! Pictured at the Denman forum are Magliery lab presenters Sarah Johnston, George Matic, Ely Porter, Tran Nguyen and Natasha Bharwani.

Nguyen wins Biological Sciences Dean's Undergraduate Research Award

Tran Nguyen was the recipient of a Dean's Undergraduate Research Award in the Biological Sciences for the spring quarter of 2009. Congratulations, Tran!

Matic wins BMPS poster award

George Matic received a poster award at the BMPS Undergraduate Research Forum on Apr. 24 for his poster, "Rational Mutations to Improve the Solubility and E. coli Expression of Human PON1, a Nerve Agent Bioscavenger." Congratulations, George!

Magliery lab undergraduates present posters for BMPS, Meek and Denman

Magliery lab undergraduate researchers Natasha Bharwani, Brad Competty, Sarah Johnston, George Matic, Tran Nguyen, and Ely Porter will present posters at the Biological, Mathematical and Physical Sciences Research Forum on Apr. 24, the Meek Lecture poster session on May 7, and the Denman Undergraduate Research Forum on May 13.

Magliery speaks at 2009 CounterACT Symposium

Prof. Magliery spoke at the 3rd Annual CounterACT Network Research Symposium in Washington, D.C., on Apr. 14.

Magliery presents seminars at Stony Brook and NYU Polytechnic

Prof. Magliery presented a seminar for the Chemistry department at SUNY Stony Brook on Apr. 9, and for the Chemical and Biological Sciences department of the Polytechnic Institute of NYU in Brooklyn on Apr. 10.

Competty completes Honors thesis, graduates

Brad Competty defended this Honors thesis in Biochemistry at the end of winter quarter. His thesis was entitled, "Production of Human Paraoxonase I (huPON1) in E. coli with Periplasmic Expression and Chaperone Co-expression." Brad graduated at the end of the quarter, and is staying with us through the spring to finish up a paper. Congratulations, Brad!

Lavinder paper on High-Throughput Thermal Scanning (HTTS) accepted to JACS

The manuscript "High-throughput thermal scanning: a general, rapid dye-binding thermal shift screen for protein engineering," by Jason Lavinder, Sanjay Hari and Brandon Sullivan, was accepted as a communication to the Journal of the American Chemical Society.

Harsch wins Travel Award to 2009 CounterACT conference

Christina Keventzidis Harsch received a Travel Award from the NIH to attend the 2009 CounterACT conference in Washington, D.C., Apr. 14-26.

Magliery presents Biochemistry, Biophysics seminars on Feb. 6 & 11

Prof. Magliery will present a seminar for the Biochemistry department on Friday, Feb. 6, at 11:30 am in 141 Bioscience Tower. He will present a seminar for the Biophysics program on Wednesday, Feb. 11, at 2:30 pm in the Smith room of the Physics Research Building

Magliery to present 'Best of BIOT' Webinar on Feb. 9

Prof. Magliery was selected to present of 'Best of BIOT' Webinar from the Biochemical Technology talks presented at the the fall ACS National Meeting in Philadelphia. Magliery will present a talk entitled, "Protein design from sequence statistics: Protein properties from consensus and correlation." from the session Biophysical & Biomolecular Symposium: Protein Engineering. The other session speaker will be Dev Sidhu, formerly of Genentech and currently at University of Toronto. The webinar will be at noon EST on Feb. 9. For information and registration, click here.

Sen joins the lab

Shila Sen, a first year Chemistry graduate student in the biological division, has joined the lab. Shila earned his integrated M.Sc. at IIT Kharagpur in Industrial Chemistry.

Magliery presents seminar for Ohio State Chemistry on Jan. 21

Prof. Magliery will speak in 2015 McPherson at 4 pm on Jan. 21.

Balakrishnan begins rotation

Rohan Balakrishnan, a first-year OSBP graduate student, will do a research rotation in the Magliery lab for the Winter quarter.

Porter wins ASC Research Scholarship

Ely Porter received a 2009 College of Arts & Sciences Research Scholarship, fully budgeted for his research in the Magliery lab. Congratulations, Ely!

 

2008

Magliery named PI of NIH U54 CounterACT project

Due to the departure of Dick Sayre to the Danforth Plant Science Center, Prof. Magliery was named principal investigator of an NIH U54 project on expression and engineering of paraoxonase-I. Sayre and George Wang are co-PIs on the project, which is funded through 2010. This project is a subcontract of the NIH U54 Center of Excellence headed by David Lenz at the U.S. Army Medical Research Institute for Chemical Defense.

Durani, Ramasubramanian advance to candidacy

Venuka Durani and Brinda Ramasubramanian both advanced to candidacy this quarter. Durani, a third year Chemistry student, passed her oral exam in mid-November, and Ramasubramanian, a fourth-year Chemistry student, completed her exam in mid-December. Congratulations, Venuka and Brinda!

Bharwani joins the lab

Natasha Bharwani, a junior Microbiology major, joined the lab in the fall quarter.

NINDS grants supplement for large-scale expression and purification

NINDS approved $50K in supplemental funding for the Magliery lab to purchase a fermentor and FPLC to expand our capabilities in large-scale expression and purification of paraoxonase-1 variants in E. coli. This supplement is part of the NIH U54 Center of Excellence headed by David Lenz at the U.S. Army Medical Research Institute for Chemical Defense.

Johnston, Nguyen join the lab

Postbaccalaureate student Sarah Johnston and undergraduate Tran Nguyen both joined the Magliery lab for the fall. Johnston earned a B.S. in Biology at University of Akron and is taking courses at Ohio State while applying to dental school. Nguyen is a junior Molecular Genetics major.

Magliery speaks at 3rd International Conference on Paraoxonases

Prof. Magliery presented a talk entitled, "Engineering PON1 for bacterial expression, solubility and drug-like properties," at the 3rd International Conference on Paraoxonases. The conference was held at UCLA Sept. 7-10 and was organized by Srinu Reddy, Diana Shih and colleagues.

Magliery NIH grant on 'Combinatorial Biophysics' funded

The National Institutes of Health funded Prof. Magliery's R01 proposal, "Combinatorial biophysics: Understanding protein stability with library approaches," through the National Institute for General Medical Sciences. The grant provides five years of funding for three students and a postdoctoral researcher to better understand the determinants of protein stability using high-throughput screening of small proteins.

Magliery named to Editorial Advisory Board of Molecular BioSystems

Prof. Magliery, who published in the first Emerging Investigators issue of Molecular BioSystems, was asked to join the Editorial Advisory Board for a term of two years, starting this September.

Magliery, group members present at ACS National Meeting in Philadelphia

Prof. Magliery, Jason Lavinder, Lihua Nie and Mohosin Sarkar gave presentations at the Fall National Meeting of the American Chemical Society in Philadelphia, Aug. 17-21. Magliery gave an oral presentation in the Biochemical Technology session Biophysical & Biomolecular Symposium: Protein Engineering, organized by Alex Lugovskoy and David Wood. The talk was entitled, "Protein design from sequence statistics: Protein properties from consensus and correlation," and coauthored by Brandon Sullivan and Venuka Durani. Posters were presented in BIOT sessions on Biophysical & Biomolecular Engineering (Lavinder, Sarkar) and Emerging Technologies (Nie).

Magliery speaks at 2008 Enzymes Gordon Conference

Prof. Magliery was selected to give an oral presentation at the 2008 Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways. The talk was entitled, "Statistical, combinatorial and rational engineering of enzymes for improved physical properties." The conference was held at the University of New England in Biddeford, Maine, July 13-18, and was organized by Lizbeth Hedstrom and Nicole Sampson (chairs) and Martin Bollinger and Phil Cole (vice-chairs).

Sullivan receives a second year of CBIP funding

Brandon Sullivan was awarded a second year of funding as an NIH Chemistry-Biology Interface Program fellow. Congratulations, Brandon!

Ertl, Mathur join Magliery group for summer undergraduate research

Sarah Ertl and Deepti Mathur have joined the Magliery lab for the summer. Sarah Ertl is a rising senior at St. Cloud State University in Minnesota, and is an NSF REU Fellow (Chemistry) this summer. Deepti Mathur is a rising junior at Cornell University (Ithaca, NY), and has returned for a second summer of research with us.

Competty receives 2008 ASC Research Scholarship

Brad Competty was awarded a College of Arts & Sciences Research Scholarship based on his work in the Magliery lab. The scholarship goes toward his tuition in the fall and winter. Congratulations, Brad!

Magliery, group members present at CERMACS 2008

The 2008 Central Regional Meeting of the American Chemical Society will be held at the Hyatt Regency in Columbus, Ohio, June 10-14. Prof. Magliery co-organized a three half-day session on Frontiers in Protein and Peptide Engineering with Prof. Dennis Bong. Magliery will speak during the session on June 11, as will graduate student Venuka Durani. Graduate students Jason Lavinder and Brandon Sullivan will present contributed talks on the afternoon of June 12. In addition, postdocs Lihua Nie and Vivek Shete, and graduate student Mohosin Sarkar, will present posters. Click here for the full program.

Hari, Thomas graduate on June 8

Sanjay Hari and Miriam Thomas, undergraduate researchers in the Magliery Lab, graduated on June 8 with bachelor's degrees. Sanjay Hari received a B.S. in Biochemistry. He completed an Honors Thesis entitled, "The Use of a Dimeric Four-helix Bundle as a Model to Study Protein Folding and Design." Sanjay will work in the Magliery Lab through July and then start his doctoral work in the Biomolecular Structure & Design Program at University of Washington, Seattle. Miriam Thomas received a B.A. in Chemistry, graduating summa cum laude. She graduated with distinction, completing an Honors Thesis entitled, "The Effects of Consensus Mutations on Yeast Enzyme Triosephosphate Isomerase." Miriam will be starting medical school at University of Toledo in the fall. Congratulations to both Sanjay and Miriam!

Sullivan, Durani present at OCCBIO 2008

Brandon Sullivan gave an oral presentation entitled, "The design and Characterization of a Consensus Triosephosphate Isomerase: An Empirical Model to Test Protein Statistics," at the 2008 Ohio Collaborative Conference on Bioinformatics at University of Toledo, Ohio, June 2-4. Venuka Durani also presented a poster on her statistical analysis of two protein families.

Magliery speaks at the MRICD Bioscience Review

Prof. Magliery will present a lecture entitled "Engineering PON1 for bacterial expression, solubility and drug-like properties," at the 16th Biennial Medical Defense Bioscience Review hosted by the U.S. Army Medical Research Institute for Chemical Defense. The conference is June 1-6 in Hunt Valley, MD.

Magliery speaks at Penn Biochemistry

Prof. Magliery will present a seminar in Biochemistry at University of Pennsylvania on May 21.

Hari, Matic win awards at 2008 Denman Forum

Sanjay Hari took third place in Math & Physical Sciences, and George Matic took second place in Biological Sciences, for poster presentations at the 2008 Denman Undergraduate Research Forum. There were 57 presenters in BioSci and 48 in MAPS this year. Congratulations, Sanjay and George!

Magliery quoted in Chemistry World article on unnatural amino acids research

Prof. Magliery was quoted in an article in RSC's Chemistry World called, "'Super-yeast' tackles unnatural proteins." The article is a comment on recent work published in JACS by Lei Wang's group to improve the incorporation of unnatural amino acids into proteins in yeast. Click here to read the article.

Competty, Porter win Mayers Summer Research Internships

Brad Competty and Ely Porter each were awarded a Mayers Summer Research Internship for their work in the Magliery lab in 2008. Brad is a senior Biology major, and Ely is a junior Biology major. Congratulations, Brad and Ely!

Undergraduates participate in campus research forums

Undergraduate researchers from the Magliery lab are participating in several campus research forums this spring. Brad Competty, Sanjay Hari and Ely Porter will participate in the Biological Science forum on April 25 and the Meek Lecture Forum on May 1. George Matic and Miriam Thomas will participate in the MAPS forum on May 7. All five of them will participate in the campus wide Denman forum on May 14.

Sarkar & Magliery paper on split-GFP engineering to examine protein interactions published in Molecular BioSystems

MolBioSyst_eiMohosin Sarkar's manuscript, "Re-engineering a split-GFP reassembly screen to examine RING-domain interactions between BARD1 and BRCA1 mutants observed in cancer patients," was accepted by Molecular BioSystems. It will appear in the Emerging Investigators issue featuring promising new researchers in chemical biology. See doi:/10.1039/b802481b.

UPDATE. The PDF is now available. See also the editorial by Tom Kodadek on the Emerging Investigators issue, and biographies of the contributors.

Magliery speaks at 2nd Annual CounterACT Symposium in Washington, D.C.

Prof. Magliery presented the research update for Project 4 of the NIH Center for Catalytic Bioscavenger Medical Defense Research at the Annual CounterACT Symposium in Washington, D.C., Apr. 15-17. That project is led by Terry Gustafson (co-PI), Christopher Hadad (PI), Tom Magliery (co-PI) and Matt Platz (co-PI).

Magliery speaks at ACS National Meeting in New Orleans

Prof. Magliery contributed an oral presentation entitled "High-throughput calorimetry: A dye-binding screen to characterize the thermodynamic properties of protein variants applied to four-helix bundle core packing," co-authored by Jason Lavinder and Sanjay Hari, to the ACS National Meeting in New Orleans, Apr. 9. The talk was during a session on New Techniques in Chemical Biology.

Sarkar and Shete win Travel Awards to CounterACT Symposium

Mohosin Sarkar and Vivek Shete both received fully-funded travel awards to the 2nd Annual CounterACT Symposium on Washington, D.C. in April. They will present a poster of their work improving the physical properties of the enzyme paraoxonase, as part of the NIH U54 Center Grant through the CounterACT program. Prof. Magliery is a co-PI of two subcontracts of the Center.

Competty, Hari win BioSci Dean's Research Fund Award

Brad Competty and Sanjay Hari were both recipients of this year's Dean's Undergraduate Research Fund Award from the College of Biological Sciences. This is the second year that Sanjay has won the award. Congratulations, Brad and Sanjay!

Nguyen joins the lab

Chau Nguyen, a first year chemistry graduate student from the biological division, has joined the Magliery lab. Chau received her B.S. in Chemistry from East Tennessee State University, doing undergraduate research with David Young there.

Porter joins the lab

Ely Porter, a junior biology major, is starting undergraduate research at the beginning of Winter quarter.

 

2007

Harsch advances to candidacy

Christina Keventzidis Harsch advanced to candidacy in the chemistry Ph.D. program on Dec. 14. Congratulations, Christina!

Hari wins ASC research scholarship for second time

Sanjay Hari was awarded an Arts & Sciences College research scholarship for the second year in a row. The funds will go directly to support his work in the Magliery lab. Congratulations, Sanjay!

Matic joins the lab

George Matic, a junior medical technology major, is starting undergraduate research in the Magliery lab in the Winter quarter.

Lee begins CBIP rotation

Hanna Lee, a first-year chemistry graduate student and Chemistry-Biology Interface Program fellow, begins a rotation in the Magliery lab the second week of November.

Magliery attends CSHL X-Ray Methods course

Prof. Magliery completed the X-Ray Methods in Structural Biology course at Cold Spring Harbor Laboratory in New York, Oct. 15-30. The course was taught by Alex McPherson (UC Irvine), Jim Pflugrath (Rigaku), Bill Furey (VA Medical Center/UPMC) and Gary Gilliland (Centocor).

 

 

Competty joins the lab

Brad Competty, a junior biology major, is starting undergraduate research in the Magliery lab in the Autumn quarter.

Sullivan, Durani win poster award at OCCBIO 2007

Brandon Sullivan and Venuka Durani took second place for student posters at the 2007 Ohio Collaborative Conference on Bioinformatics. Jason Lavinder and Lihua Nie also presented posters. The conference was hosted July 9-11 by Miami University in Oxford, Ohio. (Pictured: Lihua, Brandon, Jason and Venuka)

 

 

Sullivan becomes CBIP Fellow

Brandon Sullivan was selected to become a Fellow of the Chemistry-Biology Interface Training Program, starting Autumn 2007 when he starts his second year as an OSBP graduate student. Congratulations, Brandon!

Mathur, Veith start summer research

Deepti Mathur, a rising sophomore at Cornell University (Ithaca, NY), and Josh Veith, a rising senior at Mercyhurst College (Erie, PA), started summer research projects in the Magliery lab. Mathur is an Upper Arlington High School graduate with interests in biochemistry. Veith is a Molecular Genetics & Biochemistry NSF REU fellow majoring in biochemistry.

Sullivan officially joins the lab

Brandon Sullivan, who was a research assistant in the lab in 2005-2006 and started as an OSBP graduate student in the fall of 2006, has joined the Magliery lab.

Magliery, Lenz featured in Kenyon College Alumni Bulletin

The Spring/Summer 2007 issue of the Kenyon College Alumni Bulletin features Prof. Magliery and Dr. David Lenz in a segment called "Eye on Terrorism." The article describes the NIH Center of Excellence for which Lenz is the principal investigator, and Magliery is a co-investigator on two sub-projects. See, "Target the Toxin."

Lavinder awarded AHA Predoctoral Fellowship

Jason Lavinder, an OSBP graduate student and previous CBIP Fellow, was awarded an American Heart Association Predoctoral Fellowship from the Great River Affiliate of the AHA. The fellowship pays for Lavinder's stipend and benefits for two years. Congratulations, Jason!

Heberling to graduate with research distinction

Matt Heberling passed his Honors oral exam on May 24, certifying him for graduation with research distinction. Matt will graduate with a B.S. in biochemistry this quarter. Matt defended his thesis on the engineering and initial characterization of a computationally-designed mutant of the tumor suppressor protein p53. Congratulations, Matt!

Heberling takes third place in Biological Sciences at Denman Research Forum

Matt Heberling won third place honors in the Biological Sciences division of the 2007 Denman Undergraduate Research Forum. Matt presented his poster, "Improving the stability of tumor suppressor protein p53." There were over 300 participants in the Denman Forum this year, including about 60 in the Biological Sciences. Congratulations, Matt!

Thomas awarded 2007 University Summer Research Internship

Miriam Thomas, a third-year chemistry major, has received a 2007 Summer Research Internship from the University Honors & Scholars office, which will fund her summer work in the Magliery lab. Congratulations, Miriam!

Sullivan, Magliery speak at first annual IGP symposium May 12

Brandon Sullivan will present a talk at OSU's first annual Interdepartmental Graduate Program Symposium on May 12. Sullivan will discuss the design, engineering and characterization of a consensus triosephosphate isomerase, which he started in the fall of 2005 as a research assistant. Also, Prof. Magliery was selected by the Biophysics students to give a seminar. He will discuss, "Combinatorial approaches to protein stability and interactions."

Hari awarded 2007 Mayers Summer Research Internship

Sanjay Hari, a third-year biochemistry major, was awarded a 2007 Mayers Summer Research Internship, which funds his summer research in the Magliery group. Congratulations, Sanjay!

Thomas wins award at MAPS Research Forum

Miriam Thomas won an award for presenting a top poster at the MAPS Undergraduate Research Forum on May 9. Her poster was entitled, "The effects of consensus mutations on the yeast enzyme triosephosphate isomerase." Congratulations, Miriam!

Magliery speaks at President's Salute to Undergraduate Achievement

Prof. Magliery gave a short presentation on "Combinations & Possibilities in Protein Science" as part of the President's Salute to Undergraduate Achievement on May 2 at the Fawcett Center. Magliery presented the work of undergraduates Sanjay Hari and Matt Heberling. Chemistry was the featured department this year, with other presentations by Prof. Prabir Dutta and Prof. Heather Allen. Diana Vanek organized the event from the Chemistry side, which included hand-made beaker mugs by master glassblower Tim Henthorne for the undergraduates.

Hari, Heberling and Thomas present posters at undergraduate symposia

Undergraduates in the Magliery lab are presenting their work at several symposia this spring. Sanjay Hari and Matt Heberling presented posters at the BioSci symposium on Apr. 27 (Drake Union, 4 p.m.). Hari, Heberling and Miriam Thomas will all present at the Meek Lecture poster session on May 3 (McPherson, 5:30 p.m.), and Thomas will present her poster at the MAPS symposium on May 9 (PRB Atrium, 2 p.m.). Hari and Heberling will both present posters at the university's Denman Undergraduate Research Forum May 16 (French Field House, noon).

Magliery speaks at Wright State Apr. 13

Prof. Magliery will give a seminar for the Biochemistry & Molecular Biology department at Wright State University on Friday, Apr. 13.

Dr. Vivek Shete joins the lab

Vivekanand Shete joined the group as a postdoctoral associate at the beginning of April. Vivek comes to us from David Benson's lab at Wayne State Chemistry, where he engineered bioinorganic sensor proteins. Before that, Vivek received his M.Sc. from IIT Bombay and his B.Sc. from University of Mumbai. Vivek will focus his efforts on understanding and re-engineering paraoxonase for our collaborative work in the Center for Catalytic Bioscavenger Medical Defense Research.

Hari, Heberling win BioSci Dean's Award

Sanjay Hari and Matt Heberling were both recipients of awards from the Dean's Undergraduate Research Fund from the College of Biological Sciences for Winter 2007. Congratulations Matt and Sanjay!

Magliery speaks at career panel at Kenyon College Feb. 6

Prof. Magliery will speak as part of a Careers in Chemistry panel at Kenyon College in Gambier, Ohio, on Feb. 6. Magliery is a 1996 chemistry alum of Kenyon.

Heberling wins Bernstein Memorial Scholarship

Undergraduate Matt Heberling was the recipient of the 2007 Bernstein Memorial Scholarship from the College of Biological Sciences. The award supports the tuition of students with interests in cancer research. Congratulations, Matt!

Sarkar advances to candidacy

Mohosin Sarkar advanced to candidacy for a Ph.D. in the biological division of the the chemistry department on Jan. 25. Congratulations, Mohosin!

 

2006

Chemistry graduate students Venuka Durani and David Mata join the lab

Two first-year chemistry graduate students joined the lab at the end of autumn quarter. David Mata, who did undergraduate research with Brent Iverson at Texas, Austin, and Venuka Durani, who received an M.Sc. from IIT Bombay, officially start in the lab at the beginning of the winter quarter.

Sanjay Hari and Matt Heberling win ASC Research Scholarships

Biochemistry undergraduates Sanjay Hari and Matt Heberling both won ASC Research Scholarships from the Arts & Sciences Honors Program for their research proposals, to be carried out in the Magliery lab. Sanjay received two quarters of funding directly for his project, while Matt's scholarship will cover his tuition for the winter and spring quarters. Congratulations, Matt and Sanjay!

Chemistry graduate student Bob Woodward does CBIP rotation

Bob Woodward, a first-year graduate student in chemistry and a CBIP fellow, did a rotation in the lab the last half of autumn quarter.

NIH Center story in Columbus Dispatch

The Columbus Dispatch covered the NIH Center on the front page on Sunday, Nov. 12, 2006. See: "Lowly algae may help fight against terror."

Center for Catalytic Bioscavenger Medical Defense Research funded by NIH

A U54 Research Center of Excellence Grant, sponsored by the National Institute of Neurological Disorders and Stroke at NIH, led by David Lenz of the U.S. Army Medical Research Institute for Chemical Defense, was funded September 30. Magliery is a co-PI on two Center projects, led by Christopher Hadad (Chemistry) and Richard Sayre (Plant Cellular and Molecular Biology). The Center was proposed as a Countermeasures Against Chemical Threats (CounterACT) Research Center of Excellence, and it aims to produce therapeutic enzymes to neutralize organophosphate nerve agents using a wide array of approaches. The Center was provided with $14.5M over five years, including groups at MRICD, Ohio State, Human Biomolecular Research Institute (San Diego), Arizona State University and the Weizmann Institute (Israel). The Magliery group will work with Sayre and P. George Wang, and with Hadad, Terry Gustafson and Matt Platz, using combinatorial approaches to understand the mechanism and improve the drug-like properties of human paraoxonase I (huPON1). Ohio State's share of the Center accounts for $4.5M over five years.

Chemistry/CBIP graduate student Tiffany Sommers begins rotation

Tiffany Sommers, a first-year graduate student in chemistry and a CBIP fellow, begins her five-week rotation at the start of the autumn quarter.

Chemistry graduate student David Mata begins rotation

David Mata, a first year graduate student in chemistry, begins a rotation in the lab at the start of the autumn quarter.

Sullivan starts as OSBP graduate student

Brandon Sullivan, who was a research assistant in the Magliery lab during the 2005-2006 school year, joins the OSBP graduate program this autumn. Brandon will rotate in the Magliery lab in the spring and continue to work on protein design from sequence statistics.

Undergraduate Miriam Thomas joins the lab

Miriam Thomas, a senior chemistry major, is starting research in the Magliery group as of the beginning of the quarter.

Magliery speaks at MAPS/CBS Alumni Dinner on Sept. 14

Prof. Magliery will deliver a talk on "Combinations & Possibilities in Understanding Proteins" at an Alumni Dinner in Cincinnati on Sept. 14. The event is for alumni of the Colleges of Mathematical and Physical Sciences and Biological Sciences. Deans Richard Freeman and Joan Herbers will be in attendance.

Chemistry graduate student Scott Peachman begins rotation

Scott Peachman, an incoming first-year graduate student in chemistry, started a 4-week rotation on August 14.

Magliery speaks at NCI Frederick on July 27

Prof. Magliery is speaking at NCI Frederick in Maryland on July 27.

Magliery speaks at OCCBIO on June 30

Prof. Magliery is speaking at the Ohio Collaborative Conference on Bioinformatics on June 30 at Ohio University in Athens. Magliery will be speaking in a session organized by Gerald Alter on Protein Structure and Analysis. For more information, see the OCCBIO website.

Syu graduates with B.S. in biochemistry

Trixy Syu graduated on June 11 with a B.S. in biochemistry. Trixy will work in the lab for the summer, and then do research for a year at Academia Sinica in Taipei, Taiwan. Congratulations, Trixy!

Byeon, Syu win honorable mention in Meek poster session

Undergraduates Chang Byeon and Trixy Syu won honorable mentions in the poster session associated with the Meek Industrial Lectureship for work carried out this school year in the Magliery lab. They each win $25 and a certificate. Both will present their posters at the University's Denman Undergraduate Research Forum on May 17.

Lavinder advances to candidacy

Jason Lavinder, a third-year OSBP graduate student and CBIP fellow, advanced to Ph.D. candidacy on April 19. Congratulations!

Hari, Heberling win SURP award to do summer research

Sanjay Hari and Matt Heberling, both undergraduate biochemistry majors, have been awarded fellowships in the Summer Undergraduate Research Program. The program pays a stipend to enable summer research, which Hari and Heberling will carry out in the Magliery lab.

OSBP graduate students Wenjing Pan and John Shimko start rotations

Wenjing Pan and John Shimko, first-year graduate students in OSBP, started their 5-week rotations on May 1.

Prof. Magliery speaks at Kenyon College Chemistry

Prof. Magliery will give a seminar in the chemistry department of Kenyon College on Thursday, April 13. Magliery is a 1996 chemistry graduate of Kenyon College, in Gambier, Ohio.

OSBP graduate student Rob Byrne begins rotation

Rob Byrne, a first-year graduate student in OSBP, started his 5-week rotation on March 27.

Prof. Magliery joins CBIP

Prof. Magliery is now a faculty member in the Chemistry-Biology Interface Program.

Postdoctoral Associate Lihua Nie joins the lab

Dr. Lihua Nie joined the lab on February 23. Lihua earned her Ph.D. from the Institute of Chemistry at the Chinese Academy of Sciences in Beijing with Huimin Ma and Shuchuan Liang, synthesizing and testing compounds for nucleobase recognition. Before joining the group, she was a Humboldt Fellow at the Max Planck Institute for Chemical Ecology in Jena, Germany, with Wilhelm Boland, where she synthesized substrates to study mechanisms of leaf beetle defense.

Chemistry graduate student Brinda Ramasubramanian joins the lab

Brinda, a rotation student in the lab the first half of winter quarter, has officially joined the lab.

OSBP graduate student T.J. Gordon begins rotation

T.J. Gordon, a first-year graduate student in OSBP, started his 5-week rotation on February 6.

Chemistry graduate student Brinda Ramasubramanian starts rotation

Brinda Ramasubramanian, a first year Chemistry student in the biological division, is joining the Magliery lab this quarter (Winter 2006) as a rotation student.

Biochemistry undergraduate student Trixy Syu joins the lab

Trixy Syu, a senior Biochemistry major, is starting in the Magliery lab this quarter (Winter 2006).

Chemistry graduate student Mohosin Sarkar joins the lab

Mohosin Sarkar is joining the Magliery lab as a second year Chemistry student in the biological division. Mohosin will start at the beginning of Winter quarter.

 

2005

Prof. Magliery joins Biophysics Graduate Program

Biophysics graduate students may join the group as early as this year. Magliery is also a member of the Chemistry department's graduate program and the Ohio State Biochemistry Program. E-mail to make an appointment to discuss joining the lab.

Chemistry graduate student Christina Keventzidis joins the lab

Christina Keventzidis is joining the Magliery lab as a second year Chemistry student in the biological division.

OSBP/CBIP graduate student Jason Lavinder joins the lab

Jason Lavinder is joining the Magliery lab as a third-year student in OSBP. Jason is supported by a fellowship from the Chemistry-Biology Interface Program.

Undergraduate Chang Byeon joins the lab

Chang Byeon, a senior Chemistry major, has joined the lab. Chang has worked in the lab of Marius Clore at the NIH for the last two summers.

Magliery & Regan BMC Bioinformatics paper is available

Our paper, "Sequence variation in ligand binding sites in proteins," is now available online: doi:10.1186/1471-2105-6-240. The paper quickly received the "Highly Accessed" accolade.

Magliery & Regan chapter in GFP, Chalfie & Kain, 2nd ed., is available

The second edition of Green Fluorescent Protein: Properties, Applications and Protocols, edited by Martin Chalfie and Steven Kain, is now available. Our chapter, "Reassembled GFP: Detecting Protein-Protein Interactions and Protein Expression Patterns," is on pp. 391-405. Click here to buy the book from Wiley.

Brandon Sullivan joins lab as research assistant

Brandon Sullivan, a 2004 Ohio State biology major, started work in the lab September 8, 2005. Brandon will aid in the set-up and running of the lab, and will aid in biochemistry research.

Magliery & Regan manuscript accepted to BMC Bioinformatics

Our paper, "Sequence variation in ligand binding sites in proteins," was accepted to the open-access journal BMC Bioinformatics. The paper, which examines sequence variation in several well-characterized ligand-binding families, is an extension of of previous work published in the Journal of Molecular Biology, "Beyond consensus: statistical free energies reveal hidden interactions in the design of a TPR motif."

Magliery review now available in Med. Chem. Rev. Online

The review, "Unnatural protein engineering: producing proteins with unnatural amino acids," was published in the August 2005 issue of Med. Chem. Rev. Online. PDF

Metalloprotein and Protein Design Conference

Prof. Magliery has been invited to speak on Friday, July 28, 2005, at the Metalloprotein and Protein Design Conference in Chicago, IL, at the Millennium Knickerbocker Hotel.