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Publications from the last 10 years:

2012

Sherrer, S. M., Sanman, L. E., Xia, C. X., Bolin, E. R., Malik, C. K., Efthimiopoulos, G., Basu, A. K., and Suo, Z.* (2012) Kinetic Analysis of the Bypass of a Bulky DNA Lesion Catalyzed by Human Y-family DNA Polymerases, Chem. Res. Toxicol. in press.

Song, Q., Sherrer, S. M., Suo, Z., and Taylor, J.-S. (2012) Preparation of a site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase eta, J. Biol. Chem. in press. [Online Access]

Brown, J. A., Pack, L. R., Fowler, J. D., and Suo, Z.* (2012) Pre-Steady State Kinetic Investigation of the Incorporation of Anti-Hepatitis B Nucleotide Analogs Catalyzed by Non-Canonical Human DNA Polymerases, Chem. Res. Toxicol. 25, 225-233.[Online Access]

2011

Ma, D., Fowler, J.D., and Suo Z.*(2011) Backbone Assignment of the Little Finger Domain of a Y-Family DNA Polymerase, Biomolecular NMR Assignments. 5(2), 195-198.[Online Access]

Kirouac, K. N., Suo, Z., and H. Ling* (2011) Structural mechanism of ribonucleotide discrimination by a Y family DNA polymerase, J. Mol. Biol. 407(3), 382-390. [Online Access]

Brown, J.A. and Suo, Z.* (2011) Unlocking the Sugar 'Steric Gate' of DNA Polymerases, Biochemistry, invited review 50, 1135-1142. [Online Access][Article Featured on Biochemistry Jounal Homepage]

Brown, J.A., Pack, L.R., Fowler, J.D. and Suo Z.* (2011) Pre-Steady State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-family DNA Polymerases, Antimicrob. Agents Chemother. 55, 276-283. [Online Access][Press Release]

Brown, J.A., Pack, L.R., Sanman, L.E. and Suo Z.* (2011) Efficiency and Fidelity of Human DNA Polymerases Lambda and Beta during Gap-Filling DNA Synthesis, DNA Repair 10, 24-33. [Online Access]

Sherrer S.M., Fiala, K.A., Fowler J.D., Newmister, S.A., Pryor, J.M. and Suo Z.* (2011) Quantitative Analysis of the Efficiency and Mutagenic Spectra of Abasic Lesion Bypass Catalyzed by Human Y-family DNA Polymerases, Nucleic Acids Research 39, 609–622. [Online Access] (SI)

2010

Sherrer S.M., Beyer, D.C., Xia, C.X., Fowler J.D., and Suo Z.* (2010) Kinetic Basis of Sugar Selection by a Y-family DNA Polymerase from Sulfolobus solfataricus P2, Biochemistry 49, 10179-10186. [Online Access] (SI)

Brown, J.A., Pack, L.R., Sherrer, S.M., Kshetry, A.K., Newmister, S.A., Fowler, J.D., Taylor, J.-S. and Suo Z.* (2010) Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase Lambda, J. Mol. Biol. 403, 505-515. [Online Access] (SI)

Ma, D., Fowler, J.D., Yuan, C. and Suo Z.* (2010) Backbone Assignment of the Catalytic Core of a Y-family DNA Polymerase, Biomolecular NMR Assignments 4, 207-209 DOI: 10.1007/s12104-010-9244-7. [PubMed] (pdf)

Brown, J.A., Fowler, J.D. and Suo Z.* (2010) Kinetic Basis of Nucleotide Selection Employed by a Protein Template-Dependent DNA Polymerase, Biochemistry 49, 5504-5510. [Online Access]

Wong, J.H., Brown, J.A., Suo Z., Blum, P., Nohmi, T. and Ling, H.* (2010) Structural Insight into Dynamic Bypass of the Major Cisplatin-DNA Adduct by Y-family Polymerase Dpo4, EMBO J. 29, 2059-2069. [Online Access] (SI)

Brown, J.A., Zhang, L., Sherrer, S.M., Taylor, J.-S., Burgers, P.M.J. and Suo Z.* (2010) Pre-Steady State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta, J. Nucleic Acids 2010, 11 pages. (pdf)

Brown, J.A., Fiala, K.A., Fowler, J.D., Sherrer, S.M., Newmister, S.A., Duym, W.W. and Suo Z.* (2010) A Novel Mechanism of Sugar Selection Utilized by a Human X-family DNA Polymerase, J. Mol. Biol. 395, 282-290. (pdf) (SI)

2009

Xu, C., Maxwell, B.A., Brown, J.A., Zhang, L. and Suo Z.* (2009) Global Conformational Dynamics of a Y-family DNA Polymerase during Catalysis, PLoS Biology 7(10): e1000225. (pdf) [Press Release]

Brown, J.A. and Suo Z.* (2009) Elucidating the Kinetic Mechanism of DNA Polymerization Catalyzed by Sulfolobus solfataricus P2 DNA Polymerase B1, Biochemistry 48, 7502-7511. (pdf) (SI)

Zhang, L., Brown, J.A., Newmister, S.A. and Suo Z.* (2009) Polymerization Fidelity of a Replicative DNA Polymerase from the Hyperthermophilic Archaeon Sulfolobus solfataricus P2, Biochemistry 48, 7492-7501. (pdf) (SI)

Fowler J.D., Brown, J.A., Kvaratskhelia, M. and Suo Z.* (2009) Probing Conformational Changes of Human DNA Polymerase Lambda using Mass Spectrometry-Based Protein Footprinting, J. Mol. Biol. 390, 368-379. (pdf) (SI)

Sherrer S.M., Brown J.A., Pack L.R., Jasti V.P., Fowler J.D., Basu A.K., and Suo Z.* (2009) Mechanistic Studies of the Bypass of a Bulky Single-Base Lesion Catalyzed by a Y-family DNA Polymerase, J. Biol. Chem. 284, 6379-8863. (pdf) (SI)

2008

DeCarlo, L., Prakasha Gowda, A.S., Suo, Z. and Spratt, T.E.* (2008) Formation of Purine-Purine Mispairs by Sulfolobus solfataricus DNA Polymerase IV, Biochemistry 47, 8157-8164. (pdf) (SI)

Brown, J.A., Newmister, S.A., Fiala, K.A. and Suo, Z.* (2008) Mechanism of Double-Base Lesion Bypass Catalyzed by a Y-family DNA Polymerase, Nucleic Acids Research 36, 3867-3878. (pdf) (SI)

Wong, J.H., Fiala, K.A., Suo, Z. and Ling, H.* (2008) Snapshots of a Y-family DNA Polymerase in Replication: Substrate-Induced Conformational Transitions and Implications for Fidelity of Dpo4, J. Mol. Biol. 379, 317-330. (pdf)

Fowler, J.D., Brown, J.A., Johnson, K.A. and Suo, Z.* (2008) Kinetic Investigation of the Inhibitory Effect of Gemcitabine on DNA Polymerization Catalyzed by Human Mitochondrial DNA Polymerase. J. Biol. Chem. 283, 15339-15348. (pdf) (SI)

Fiala, K.A., Sherrer, S.M., Brown, J.A. and Suo, Z.* (2008) Mechanistic Consequences of Temperature on DNA Polymerization Catalyzed by a Y-family DNA Polymerase, Nucleic Acids Research 36, 1990-2001. (pdf) (SI)

2007

Brown, J.A., Duym, W.W., Fowler, J.D. and Suo, Z.* (2007) Single-Turnover Kinetic Analysis of the Mutagenic Potential of 7,8-Dihydro-8-oxoguanine during Gap-Filling Synthesis Catalyzed by Human DNA Polymerases Lambda and Beta, J. Mol. Biol. 367, 1258-1269. (pdf)

Fiala, K.A., Brown, J.A., Ling, H., Kshetry, A.K., Zhang, J., Taylor, J.-S., Yang, W. and Suo, Z.* (2007) Mechanism of Template-Independent Nucleotide Incorporation Catalyzed by a Template-Dependent DNA Polymerase, J. Mol. Biol. 365, 598-610. (pdf)

Fiala, K.A., Hypes, C. and Suo, Z.* (2007) Mechanism of Abasic Lesion Bypass Catalyzed by a Y-family DNA Polymerase, J. Biol. Chem.282, 8188-8198. (pdf) (SI) [Press Release]

Fiala, K.A. and Suo, Z.* (2007) Sloppy Bypass of an Abasic Lesion Catalyzed by a Y-family DNA Polymerase. J. Biol. Chem. 282, 8199-8206. (pdf) (SI) [Press Release]

Abdullah, M.A.F. and Suo, Z.* (2007) Unique Composite Active Site of the Hepatitis C Virus NS2-3 Protease: A New Opportunity for Antiviral Drug Design. Chem. Med. Chem. 2, 283-284. (pdf)

2006

Duym, W.W., Fiala, K.A., Bhatt N. and Suo, Z.* (2006) Kinetic Effect of a Downstream Strand and Its 5’-Terminal Moieties on Single-Nucleotide Gap-Filling Synthesis Catalyzed by Human DNA Polymerase Lambda. J. Biol. Chem. 281, 35649–35655. (pdf)

Fiala, K.A., Duym, W.W., Zhang, J. and Suo, Z.* (2006) Up-regulation of the Fidelity of Human DNA Polymerase Lambda by Its Non-enzymatic Proline-rich Domain, J. Biol. Chem. 281, 19038-44. (pdf) [Press Release]

Fowler, J.D. and Suo, Z.* (2006) Biochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase. Chem. Rev., 106(6), 2092-110. (pdf)

2005

Suo, Z.* (2005) Thioesterase Portability and Peptidyl Carrier Protein Swapping in Yersiniabactin Synthetase from Yersinia pestis. Biochemistry 44, 4926-4938. (pdf)

Johnson, A.A., Fiala, K.A. and Suo, Z.* (2005) Chapter 6: DNA Polymerases and Their Interactions with DNA and Nucleotides, pp133-168. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Abdel-Gawad, W., Tan, S. L. and Suo, Z.* (2005) Chapter 7: RNA polymerases, pp169-206. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Wang, L. and Suo, Z.* (2005) Chapter 8: Reverse Transcriptase, pp207-246. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

2004

Fiala, K.A. and Suo, Z.* (2004) Pre-Steady State Kinetic Studies of the Fidelity of Sulfolobus solfataricus P2 DNA Polymerase IV, Biochemistry 43, 2106-2115. (pdf)

Fiala, K.A. and Suo, Z.* (2004) Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA Polymerase IV, Biochemistry 43, 2116-2125. (pdf)

Zhang G. and Suo, Z.* (2004) A Mild and Convenient Synthetic Method for Arylhydrazones of Methyl Benzoate, Synthetic Communications 34 (4), 673-678. (pdf)

Fiala, K.A., Abdel-Gawad, W. and Suo, Z.* (2004) Pre-Steady-State Kinetic Studies of the Fidelity and Mechanism of Polymerization Catalyzed by Truncated Human DNA Polymerase Lambda, Biochemistry 43, 6751-6762. (pdf)

Roettger, M.P., Fiala, K.A. and Suo. Z.* (2004) Fidelity of Human DNA Polymerase Mu, Biochemistry 43, 13827-13838. (pdf)

2001

Allison, A.J., Ray, A., Suo, Z., Colacino, J.M., Andeson, K.S. and Johnson, K.A. (2001) Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase, J. Biol. Chem. 276, 40847-40857.

Suo, Z., Tseng, C. and Walsh, C.T. (2001) Purification, Priming, and Catalytic Acylation of Carrier Protein Domains in the Polyketide Synthase and Nonribosomal Peptidyl Synthetase Modules of the HMWP1 Subunit of Yersiniabactin Synthetase, Proc. Natl. Acad. Sci. U.S.A. 98, 99-104.

2000

Suo, Z., Chen, H. and Walsh, C. T. (2000) Acyl CoA Hydrolysis by the HMWP1 Subunit of Yersiniabactin Synthetase: Mutational Evidence for A Cascade of Four Acyl-Enzyme Intermediates during Hydrolytic Editing, Proc. Natl. Acad. Sci. U.S.A. 97, 14188-14193.

Keating, T.A., Suo, Z., Ehmann, D.D. and Walsh, C.T. (2000) Selectivity of the Yersiniabactin Synthetase Adenylation Domain in the Two Step Process of Amino Acid Activation and Transfer to a Holo-Carrier Protein, Biochemistry 39, 2297-2306.