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Claudia Turro received her B.S. with Honors in 1987 from Michigan State University. She worked with Daniel G. Nocera and George E. Leroi at Michigan State University and received her Ph.D. in 1992. She was awarded a Jane Coffin Childs Memorial Fund for Medical Research Postdoctoral Fellowship to continue postodoctoral work at Columbia University with Nicholas J. Turro from 1992 to 1995. She has been a faculty member at The Ohio State University since 1996. She received the Early CAREER Award by the National Science Foundation in 1998, the Arnold and Mabel Beckman Foundation Young Investigator Award in 1999, was named a 2010 Fellow of the American Chemical Society, and a 2012 Fellow of the American Association for the Advancement of Science. She was elected Vice Presdient (2010-12) and President of the Inter-American Photochemical Society (2012-14), and Chair of the Bioninorganic Subdivision of the Division of Inorganic Chemistry of the American Chemical Society (2013-14). She received the College of Arts and Sciences inaugural Susan M. Hartmann Mentoring and Leadership Award (2014) and the 2014 Inter-American Photochemical Society Award in Photochemistry.
Inorganic Photochemistry, Excited State Processes, Control of Charge Separation and Recombination, Solar Energy Conversion
The Turro group is interested in understanding and utilizing reactions of metal complexes that can be initiated with light. The potential applications of these reactions span the areas of photodynamic therapy (PDT) for the treatment of tumors, luminescent reporters and sensors, degradation of pollutants triggered by light, and solar energy conversion. In order to improve and expand their reactivity, the fundamental understanding of the excited states of mononuclear and dinuclear metal-metal bonded transition metal complexes is necessary and remains an important subject of investigation. This work is currently funded by the National Science Foundation. The work in the Turro group continues to address long-range charge transport, as well as the chemical control of charge separation and charge recombination. Understanding and controlling these processes is vital for efficient solar energy conversion. Transition metal complexes that are nontoxic in the dark and become highly toxic upon irradiation with visible or near-IR light are ideal for PDT. Complexes that undergo photo-induced ligand-loss are under investigation, such that the complex can covalently bind to DNA following photolysis and disrupt cellular processes in a manner similar to cisplatin, while simultaneously releasing drugs. This work is currently supported by the National Institutes of Health. The Turro group has also discovered new materials that are able to both harvest photons and undergo catalytic transformations to prodcuce clean fuels. This work is currently funded by the Department of Energy.
Selected Recent Publications
“DNA Light-Switch Behavior Observed for a Non-Intercalating Complex” Daniel A. Lutterman, Abdellatif Chouai, Yujie Sun, Cristina D. Stewart, Kim R. Dunbar, and Claudia Turro, J. Am. Chem. Soc. 2008, 30, 1163-1170.
“The Remarkable Influence of M2 σ to Thienyl π Conjugation in Oligothiophenes Incorporating MMQuadruple Bonds” Burdzinski, G., Chisholm, M. H.; Chou, P.-T.; Feil, F.; Chou, Y.-H.; Gallucci, J.; Ghosh, Y.; Gustafson, T.; Ho, M.-N.; Liu, Y.; Ramnauth, R.; Turro, C. Proc. Natl. Acad. Sci., 2008, 105, 15247-15252.
“Ultrafast Ligand Exchange: Detection of a Pentacoordinate Ru(II) Intermediate and Product Formation” Yao Liu, David B. Turner, Tanya N. Singh, Abdelatif Chouai, Kim R. Dunbar, and Claudia Turro, J. Am. Chem. Soc. 2009, 131, 26-27.
“Cell Cytotoxicity Studies of Dirhodium(II,II) Complexes: Documentation of Antitumor Active Dirhodium Compounds Interactions with Nuclear DNA” J. Dafhne Aguirre, Alfredo M. Angeles-Boza, Abdellatif Chouai, Jean-Philippe Pellois, Claudia Turro, and Kim R. Dunbar, J. Am. Chem. Soc. 2009, 131, 11353-1136.
“Ultrafast Dynamics of the Low-Lying 3MLCT States of [Ru(bpy)2(dppp2)]2+” Yujie Sun, Yao Liu, and Claudia Turro, J. Am. Chem. Soc. 2010, 132, 5594-5595.
“Highly Solvent Dependent Luminescence from [Ru(bpy)n(dppp2)n–3]2+ (n = 0 - 2)” Yujie Sun and Claudia Turro, Inorg. Chem. 2010, 49, 5025–5032.
“Effect of Electronic Structure on the Photoinduced Ligand Exchange of Ru(II) Polypyridine Complexes” Robert N. Garner, Lauren E. Joyce, and Claudia Turro, Inorg. Chem. 2011, 50, 4384-4391.
“Light Activation of a Cysteine Protease Inhibitor: Caging of a Peptidomimetic Nitrile with RuII(bpy)2” Tomasz Respondek, Robert N. Garner, Mackenzie K. Herroon, Izabela Podgorski, Claudia Turro and Jeremy J. Kodanko, J. Am. Chem. Soc. 2011, 133, 17164-17167.
“To Intercalate or Semiintercalate, or Both?” Claudia Turro, invited commentary, Proc. Natl. Acad. Sci. USA 2011, 108, 17573-17574.
Binding Manners” interview for Nature Chemistry 2012, 4, 591.
“Excited State Dynamics of Ru(II) Cycometallated Dyes: Relation to Cells for Solar Energy Conversion and Comparison to Conventional Systems”, Bruno Peña, Nicholas A. Leed, Kim R. Dunbar, and Claudia Turro, J. Phys Chem. C. 2012, 116, 22186–22195.
“Photochemistry and DNA Photocleavage by a new Unsupported Dirhodium(II,II) Complex”, invited submission for a special issue on “Photoactivated Metal Complexes: from Theory to Therapeutics”, Zhanyong Li, Scott J. Burya, Claudia Turro, and Kim R. Dunbar, Phil. Trans. A 2013, 371:20120128.
“Cytotoxcity of Cyclometallated Ruthenium Complexes: The Role of Ligand Exchange on the Activity”, invited submission for a special issue on “Photoactivated Metal Complexes: from Theory to Therapeutics”, Alycia Palmer, Bruno Peña, R. Bryan Sears, Oliva Chen, Maya El Ojaimi, Randolph P. Thummel Kim R. Dunbar, and Claudia Turro, Phil. Trans. A 2013, 371:20120135.
“Photoinduced Ligand Exchange and DNA Binding of cis-[Ru(phpy)(phen)(CH3CN)3]2+ in the PDT Window”, R. Bryan Sears, Lauren E. Joyce, Maya Ojaimi, Judith C. Gallucci, Randolph P. Thummel, and Claudia Turro, J. Inorg. Biochem. 2013, 121, 77-87.
"Cellular Toxicity Induced by the Photorelease of a Caged Bioactive Molecule: Design of a A Potential Dual-Action Complex" Mark A. Sgambelloene, Amanda David, Robert N. Garner, Kim R. Dunbar, and Claudia Turro, J. Am. Chem. Soc. 2013, 135, 11274-11282.
“Selective Photoinduced Ligand Exchange in a New Tris-Heteroleptic Ru(II) Complex” by Bryan A. Albani, Christopher B. Durr, and Claudia Turro, invited submission for an issue in honor of Terry A. Miller, J. Phys. Chem. A, 2013, 117, 13885-92.
“Directional Charge Transfer and Highly Redox Active Excited States of New Dirhodium(II,II) Complexes: Potential Applications in Solar Energy Conversion” Zhanyong Li, Nicholas A. Leed, Nicole M. Dickson-Karn, Kim R. Dunbar, and Claudia Turro, Chem. Sci. 2014, 5, 727-737.
“Photoinduced Intercalation and Coordination of a Dirhodium Complex to DNA: Dual DNA Binding”, Alycia M. Palmer, Scott J. Burya, Judith C. Gallucci, and Claudia Turro, ChemMedChem 2014, 9, 1260-1265.
“A Tripodal Monopeptide Ligand for Asymmetric Rh(II) Catalysis Highlights Unique Features of On-Bead Catalyst Development”, Ramya Sambasivan, Wenwei Zheng, Scott J. Burya, Bryan V. Popp, Claudia Turro, Cecilia Clementi, and Zachary T. Ball, Chemical Science 2014, 5, 1401-1407.
“Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound”, Tomasz Respondek, Rajgopal Sharma, Mackenzie K. Herroon, Robert N. Garner, Jessica D. Knoll, Eric Cuenty, Claudia Turro, Izabela Podgorski, and Jeremy J. Kodanko, ChemMedChem 2014, 9, 1306-1315.
“Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Appliations for Ruthenium Dyes”, Bruno Peña, Amanda David, Christiane Pavani, Mauricio S. Baptista, Jean-Philippe Pellois, Claudia Turro, and Kim R. Dunbar, Organometallics 2014, 22, 1100-1103.
"New Cyclometallated Ruthenium Complex for Potential Application in Photochemotherapy?" Albani, B. A.; Peña, B.; Dunbar, K. R.; Turro, C., Invited paper for special issue in memory of Nicholas J. Turro, Photochem. Photobiol. Sci. 2014, 13, 272-280.
“Control and Utilization of Ruthenium and Rhodium Metal Complex Excited State for Photoactivated Cancer Therapy" Jessica D. Knoll and Claudia Turro, Coord. Chem. Rev. 2014, in press.
"Confocal Fluorescence Microscopy Studies of a Fluorphore-Labeled Dirhodium Compound: Visualizing Metal–Metal Bonded Molecules in Lung Cancer (A549) Cells", Peña, B.; Barhoumi, R.; Burghardt, R. C.; Turro, C.; Dunbar, K. R. J. Am. Chem. Soc. 2014, 136, 7861-7864. (DOI: 10.1021/ja503774m)
"Ruthenium Tris(2-pyridyl)amine as an Effective Photocaging Group for Nitriles" Sharma, R.; Knoll, J. D.; Martin, P. D.; Podgorski, I.; Turro, C.; Kodanko, J. J. Inorg. Chem. 2014, 53, 3272-3274.
"Unusually Efficient Pyridine Photodissociation from Ru(II) Complexes with Sterically Bulky Bidentate Ancillary Ligands" Jessica D. Knoll, Bryan A. Albani, Christopher B. Durr, and Claudia Turro, J. Phys. Chem. A, 2014, in press.
"Electronic Tuning of the Ligation Sphere for Optimal Photochemotherapy in Oxypyridine Bridged Dirhodium(II,II) Complexes" Zhanyong Li, Amanda David, Bryan A. Albani, Jean Philippe Pellois, Claudia Turro, and Kim R. Dunbar, J. Am. Chem. Soc. 2014, in press.
"Marked Improvement of Photoinduced Cell Death by a New Tris-Heteroleptic Complex with Dual Action: 1O2 Sensitization and Ligand Dissociation", Bruno Peña, Bryan A. Albani, Nicholas Leed, Christiane Pavani, Mauricio S. Baptista, Kim R. Dunbar, and Claudia Turro, J. Am. Chem. Soc. 2014, in press.