2014 Paquette Legacy Symposium

Friday, May 9, 2014
1015MP -- 1:00PM Lectures

Invited Lecturers

Scott D. Edmondson, Ph.D.

Director, Discovery Chemistry
Merck Research Laboratories
Kenilworth, New Jersey USA

Scott D. Edmondson received a Bachelor of Arts degree in chemistry from Cornell University in 1991. He earned his Ph.D. from The Ohio State University in 1996 where he applied anionic oxy-Cope rearrangements to the synthesis of terpene natural products with Leo Paquette. After two years as an NIH postdoctoral fellow with Samuel Danishefsky at Columbia University, he joined the Department of Medicinal Chemistry at Merck in Rahway, New Jersey in 1998.

At Merck, Dr. Edmondson has worked in a broad range of therapeutic areas including obesity, diabetes, urology, and cardiovascular diseases. He was a co-inventor of Januvia, a DPP-4 inhibitor currently used to treat patients with type 2 diabetes, and he led a project to the discovery of MK-4618 which recently completed Phase 2 clinical trials for the treatment of overactive bladder. From 2011-13, he was the chemistry lead for nascent cardiovascular disease programs at Merck. Dr. Edmondson is a co-author of more than 30 publications, 3 book chapters, and 40 patents/patent applications. Currently, he is Director of Discovery Chemistry at Merck in Kenilworth, NJ where he works in the exploratory chemistry group and is responsible for leading an early stage anti-thrombosis program.

Eric Jacobsen, Ph.D.

Sheldon Emory Professor of Organic Chemistry
Chair, Harvard University

Eric Jacobsen received his B.S. degree from New York University in 1982. His Ph.D. work was done at U.C. Berkeley under the direction of Robert Bergman. In 1986, he returned to the East Coast of the U.S. for an NIH postdoctoral fellowship at MIT with Barry Sharpless. In 1988, he began his independent career on the faculty at the University of Illinois. He moved to Harvard University as full professor in the summer of 1993, and he was named the Sheldon Emory Professor of Organic Chemistry in 2001, and Department Chair in 2010.

Eric Jacobsen directs a research group of 20 graduate students and postdocs dedicated to discovering useful catalytic reactions, and to applying state-of-the art mechanistic and computational techniques to the analysis of those reactions. Several of the catalysts developed in his labs have found widespread application in industry and academia. These include metal-salen complexes for asymmetric epoxidation, conjugate additions, and hydrolytic kinetic resolution of epoxides; chromium-Schiff base complexes for a wide range of enantioselective pericyclic reactions; and organic hydrogen bond-donor catalysts for activation of neutral and cationic electrophiles. Jacobsen's mechanistic analyses of these systems have helped uncover general principles for catalyst design, including electronic tuning of selectivity, cooperative homo- and hetero-bimetallic catalysis, hydrogen-bond donor asymmetric catalysis, and anion binding catalysis.

Peter Wipf, Ph.D.

Distinguished University Professor of Chemistry
Professor of Pharmaceutical Sciences
Director, Center for Chemical Methodologies and Library Development

Peter Wipf received his Dipl. Chem. in 1984 and his Ph.D. in 1987 from the University of Z├╝rich under the direction of Professor Heinz Heimgartner. After a Swiss NSF postdoctoral fellowship with Professor Robert E. Ireland at the University of Virginia, Wipf began his appointment at the University of Pittsburgh in the fall of 1990. Since 2004, he is a Distinguished University Professor of Chemistry and a Professor of Pharmaceutical Sciences. He also serves as the Director of the Center for Chemical Methodologies and Library Development (UPCMLD) and is a co-Leader of the UPCI Molecular Therapeutics and Drug Discovery Program.

Peter Wipf's research focuses on the total synthesis of natural products, organometallic and heterocyclic chemistry. Among recent awards, he is a recipient of the Mosher Award and the Morley Medal (2013) and the Ernest Guenther Award in the Chemistry of Natural Products (2009). In 1998, he received the Arthur C. Cope Scholar Award. He is a Fellow of the American Chemical Society (2010), the Royal Society of Chemistry (FRSC, 2004), and the American Association for the Advancement of Science (AAAS, 2002). He has been an Associate Editor of ACS Med. Chem. Lett. since 2009 and serves on the Board of Directors of Organic Syntheses (since 2013) and Organic Reactions (since 2007).

2014 Leo Paquette Legacy Symposium

Dr. Leo Paquette
Friday, May 9, 2014
1015MP -- 1:00PM Lectures
Reception Immediately Following in 2136NW

The Leo A. and Estelle I. Paquette Professorship Endowment Fund will carry on Dr. Paquette’s legacy and you can contribute in one of two ways:

  1. Online at giveto.osu.edu
  2. Make a check payable to "The Ohio State University Department of Chemistry" and note "Leo and Estelle Paquette Faculty Research Fund" on the memo line. Please send checks to:
Therese O'Donnell-Leonard
The Ohio State University Dept. of Chemistry & Biochemistry
2128 Newman Wolfrom Lab
100 W. 18th Ave.
Columbus, OH 43210

For Further Information