2019 David J. Hart Symposium

Image
Scott Snyder
October 30, 2018
All Day
Location
CBEC 130

Description

Scott Snyder, University of Chicago

Room: CBEC 130

Strategies and Tactics for the Rapid Synthesis of Molecular Complexity

The total synthesis of natural products has long served as a principal driving force for discovering new chemical reactivity, evaluating physical organic theories, testing the power of existing synthetic methods, and enabling biology and medicine. Indeed, retrosynthetic analysis, carbodiimide-based peptide coupling reagents, cation-π cyclizations, frontier molecular orbital theory, chiral auxiliaries, catalysts for asymmetric reactions, protecting groups, and several designed pharmaceuticals are but a few of the landmark achievements that have derived from its inspirational power.  Hundreds of equally important discoveries remain, and our research program seeks to unearth some of those treasures. 

This talk will highlight our recent efforts to utilize alkaloid and terpene-based targets as effective sources of chemical inspiration.  These endeavors have led to the development of unique strategies to form polycyclic frameworks, the identification of widely applicable reaction sequences for targets of diverse biosynthetic origin, and unique thoughts on how quaternary centers can be used to facilitate complex molecule synthesis.

The David J. Hart Lectures

 

Head shot of David Hart

David J. Hart was born in Lansing, Michigan on May 15, 1948. He graduated from Okemos High School in 1966 and attended Antioch College in Yellow Springs, Ohio from 1966-1967. During the Vietnam War era he was drafted and served as a conscientious objector from 1967-1969. He then returned to undergraduate school at the University of Michigan where he received his BS degree in chemistry in 1972 with support from a Moses Gomberg Fellowship. He received his B.S. from the University of California at Berkeley in 1976 where he studied with William G. Dauben. After two years as an NIH postdoctoral fellow at the California Institute of Technology with David A. Evans, he joined the Department of Chemistry at The Ohio State University in 1978. He was promoted to Associate Professor in 1983 and Professor in 1988.

Hart became interested in organic synthesis during his undergraduate days and was particularly influenced by a course he took from Richard Lawton at the University of Michigan. His research has focused on the development of synthetic methods and their application to problems in the field of natural products synthesis. His research group is perhaps best known for their contributions to the field of free radical chemistry, but has also contributed to the development of N-trimethylsilylimines as synthetic intermediates, stereochemical aspects of N-acyliminium ion chemistry, synthetic and mechanistic aspects of ester enolate-imine condensation reactions, and several other topics relevant to the field of organic chemistry. His interest in natural products synthesis has included work on alkaloids, terpenoids, β-lactam antibiotics and carbohydrates.

Early in his career at OSU, Hart was named an Eli Lilly Fellow (1982-1984), Alfred P. Sloan Fellow (1983), OSU Distinguished Scholar (1983-1987), and received the Zeneca Award for Excellence in Chemical Research (1986). More recently he received the Columbus ACS Section Award (2000), and the OSU Alumni Association Distinguished Teaching Award (2001). In 2007 he was named Melvin S. Newman Professor of Chemistry. Hart served on the Editorial Boards of the Journal of Organic Chemistry (1986-1990) and Organic Syntheses (1992-2000), as a section editor for the Encyclopedia of Reagents for Organic Synthesis (1993-1995), as chairman of the 1991 Gordon Research Conference on Heterocyclic Compounds, and as a member of the NIH Medicinal Chemistry Study Section (1992-1996). He also served for three years as a member of the Executive Committee of the ACS Division of Organic Chemistry (1999-2001) and was the Vice Chair for Graduate Studies at OSU from 2002-2005. He was also a visiting professor at Harvard University (1987), UC Berkeley (1988), the Kyoto Institute of Technology (2000), and was a National Science Council of Taiwan lecturer in 1995.

Hart served as advisor to over 40 PhD students, 25 MS students, 15 postdoctoral fellows, and numerous undergraduate and high school students. He has published over 130 papers presented over 170 invited lectures describing their work.

Hart seems to have a genetic connection to chemistry. His grandfather (David Hart) was an inorganic chemist and his father (Harold Hart) was an organic chemist on the faculty at Michigan State University for 41 years. His mother (Geraldine) is not a chemist, but his older sister (Leslie) teaches general and organic chemistry at Central Connecticut State University. Hart has two more sisters (Ariel and Diana) and they are not chemists, although they both are teachers. Hart has been married to Rose (a mathematics teacher at OSU-Newark) for 17 years, is stepfather to Lyla and Nick (both OSU graduates), and grandfather to Ruben. Hart is a dedicated Detroit Tiger fan and likes to play golf.

Previous Lecturers:

2018 - John Wood

2017 - Barry Trost

2016 - Sarah E. Reisman

2015 - Erik Sorensen

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