The Analytical Chemistry Program at Ohio State is focused on the fundamentals of analysis and measurement. Our faculty engage in research that creates new types of measurements, and hence new capabilities for analyses. These efforts are driven by emerging research areas, including structural biology, energy and catalysis, analytical separations and diagnostics. Our Ph.D. program is strongly augmented by the vast instrumentation and cutting-edge facilities, including the CCIC Mass Spectrometry and Proteomics Facility which is managed by Ohio Eminent Scholar and Professor Vicki Wysocki, providing state-of-the-art instrumentation and personnel expertise for a wide variety of research projects. Our students graduate with a strong sense of confidence in analytical method development, instrumentation and molecular characterization.
The complexity of contemporary research requires interdisciplinary efforts, and chemical instrumentation and new analytical method development are poised to play important roles. In this instrument from the Baker lab, femtosecond soft x-ray reflection-absorption spectroscopy is performed on a table-top, home-build instrument to enable the studies of interfacial charge transfer reactions, which are important in controlling the selectivity and efficiency of catalytic energy conversion processes.
Imaging mass spectrometry can reveal drug distribution. In research performed by the Hummon lab, the penetration and metabolism of the chemotherapeutic irinotecan was imaged in colon cancer three-dimensional cell cultures by MALDI mass spectrometry. The distribution of three metabolites (c, d, e) are compared against the prodrug (f) to determine their locations within the tumor spheroid.
In the Schultz lab, surface enhanced Raman detection has been incorporated into an online flow detector compatible with liquid chromatography and capillary electrophoresis separations. As molecules pass from a separation capillary, sheath-flow confines them near a SERS substrate enabling chemical specific and quantitative detection, such as for the cocaine metabolite, benzoylecgonine, shown.
- Laser spectroscopy
- Mass spectrometry and proteomics
- Molecular biophysics