Magnetic Resonance Laboratory - NMR and EPR

Magnetic Resonance Laboratory - NMR and EPR

Fun Facts
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The NMR Facility is located in the basement of the CBEC Building (092) and Evans Laboratory (EL 0083 & EL 0086).  Current instrumentation includes six solution-state spectrometers and one solid-state spectrometer. Each instrument is configured with unique capabilities and optimized for a large variety of experiments to meet the needs of interested research groups, undergraduate students, and industrial clients.

The EPR Facility is located in the basement of the CBEC Building (079) and includes an EMX-Plus EPR spectrometer and a benchtop ESR5000 EPR spectrometer [coming 2021]. These instruments are both continuous-wave (CW), X-band EPR spectrometers and are available in both room temperature and cryogenic temperature operating modes.

Routine maintenance and repairs are provided by the NMR Facility Staff and the CBC Instrumentation Support Group.

 

Higher field instruments optimized for bioNMR applications are part of the Campus Chemical Instrument Center (CCIC) and the upcoming National Gateway Ultrahigh Field NMR Center, managed and operated by the Office of Research.

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Chen, D., Zhu, X., Ilavsky, J., Whitmer, T.L., Hatzakis, E., Jones, O., Campanella, O.; Polyphenols weaken pea protein gel by formation of large aggregates with diminished non-covalent interactions, Biomacromolecules 2021, 22, 1001. DOI: 10.1021/acs.biomac.0c01753.

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Chase M. Kayrouz, Yeying Zhang, Tiffany M. Pham, and Kou-San Ju; Genome Mining Reveals the Phosphonoalamide Natural Products and a New Route in Phosphonic Acid Biosynthesis; ACS Chemical Biology 2020 15 (7), 1921-1929 DOI: 10.1021/acschembio.0c00256.

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R. Z. Pavlović, L. Zhiquan, M. Güney, R. F. Lalisse, R. G. Hopf, J. Gallucci, C. Moore, H. Xie, C. M. Hadad, J. D. Badjić; Multivalent C−H⋅⋅⋅Cl/Br−C Interactions Directing the Resolution of Dynamic and Twisted Capsules; Chem. Eur. J. 201925, 13124. DOI: 10.1002/chem.201903006.

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Spectrometers Available

The NMR Facility is located in the basement of the CBEC Building (092) and Evans Laboratory (EL 0083 & EL 0086).  Current instrumentation includes six solution-state spectrometers and one solid-state spectrometer. Each instrument is configured with unique capabilities and optimized for a large variety of experiments to meet the needs of interested research groups, undergraduate students, and industrial clients.

Solution NMR

600 MHz Avance III HD -  This is our most versatile instrument in the facility, capable of a large number of NMR experiments ranging from routine to advance multidimensional, multinuclear NMR, water suppression, and variable temperature.  Most experiments can be acquired using automation.    

400 MHz Avance NEO  - This instrument is a walkup instrument utilizing a SampleJet and a liquid nitrogen cooled probe (Prodigy) enhanced sensitivity and for high sample through-put.

400 MHz Avance III  - This is a walk-up instrument which utilizes the SampleJet for high sample through-put.

400 MHz DPX  - Currently, we are using this instrument for routine 1H, 13C, and 31P experiments and variable temperature studies.

250 MHz DPX  - Primarily a walk-up instrument equipped with a quarternary probe for detection of X (carbon, phosphorus, and boron) nuclei.

80 MHz Benchtop - Primarily for demonstration & education.

 

Solid-state NMR

500 MHz Varian in CBEC 92 - This instrument is available via collaboration with the NMR Laboratory staff. 

 

Electron Spin/Polarization Resonance - EPR

The EPR Facility is located in the basement of the CBEC Building (079) and includes an EMX-Plus EPR spectrometer and a benchtop ESR5000 EPR spectrometer [coming 2021]. These instruments are both continuous-wave (CW), X-band EPR spectrometers and are available in both room temperature and cryogenic temperature operating modes.

EMX-Plus EPR – CBEC 079

ESR5000 Benchtop EPR – CBEC 079 (COMING SOON!)

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Staff

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Dr. Tanya Whitmer

Director of Research Support Services
Magnetic Resonance Laboratory Manager
whitmer.54@osu.edu
u.osu.edu/cbcnmr


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Dr. Dan Conroy

Magnetic Resonance Laboratory Assistant Manager
conroy.120@osu.edu
u.osu.edu/cbcnmr