Biography

Alicia Friedman is a central Ohio native, having been born and raised in the suburb of Westerville before moving away to pursue her education. She received her BA degree from Vanderbilt University (Nashville, TN)  with a major in Chemistry and a minor in Biological Sciences. She then completed her PhD in Analytical Chemistry with a focus in Chemical Biology at Indiana University (Bloomington, IN). During this time, she worked in the laboratory of Prof. Lane Baker on a wide variety of multidisciplinary projects:  

• development of synthetic hydrogels that mimic the complex selectivity of the Nuclear Pore Complex 
• development of biomimetic probes to simultaneously measure sample topography and chemical information with scanning probe microscopy (SICM) 
• XPS analysis to study the microheterogeneity of Nafion polymer membranes (most common proton-exchange material used in fuel-cell technologies) 

Alicia joined the department in 2019 and manages both the Biophysical Interaction and Characterization Facility and the Mass Spectrometry Facility.  

Research Interests 

• Mass Spectrometry: 
  • Nano-ESI
  • Novel sampling/sample introduction
• Bioanalytical Systems: 
  • Biomimetic system development 
  • Protein characterization 
• Nanotechnology:  
  • Nanoporous platforms, nanofluidics, nanoparticles 
  • Small volume/single-cell analysis 

 

Relevant Publications 

• Friedman, A. K.; Boeynaems, S.; Baker, L. A. Synthetic Hydrogel Mimics of the Nuclear Pore Complex for the Study of Nucleocytoplasmic Transport Defects in C9orf72 ALS/FTD. Anal. Bioanal. Chem. 2022, 414, 525-532. (DOI: 10.1007/s00216-021-03478-2) 
• Friedman, A. K.*; Shi, W.*; Losovyj, Y.; Siedle, A. R.; Baker, L. A. Mapping Microscale Chemical Heterogeneity in Nafion Membranes with X-ray Photoelectron Spectroscopy. J. Electrochem. Soc. 2018, 165, H733-H741. (DOI: 10.1149/2.0771811jes) 
• Shi, W.; Friedman, A.K.; Baker, L.A. Nanopore Sensing. Anal. Chem. 2017, 89, 157-188. (DOI: 10.1021/acs.analchem.6b04260) 
• Friedman, A.K.; Baker, L. A. Synthetic Hydrogel Mimics of the Nuclear Pore Complex Display Selectivity Dependent on FG-Repeat Concentration and Electrostatics. Soft Matter 2016, 12, 9477-9484. (DOI: 10.1039/C6SM01689H) 
• Friedman, A.K.; Baker, L. A. Nanopores and Nanoporous Membranes, in Nanoelectrochemistry; Mirkin, M.V.; Amemiya, S., eds.; CRC Press: Boca Raton, FL, 2015; pp 395-438. (DOI: 10.1201/b18066) 
• Morris, C. A.; Friedman, A. K.; Baker, L. A. Applications of Nanopipettes in the Analytical Sciences. Analyst 2010, 135, 2190-2202. (DOI: 10.1039/c0an00156b)