Title: "New Synthetic Methods for C–F Bond Formation: From Fundamental Science to Applications"
This presentation will describe our group's recent advances in developing metal-mediated/catalyzed methods for introducing fluorine into organic molecules. Our efforts into this area are guided by detailed fundamental studies of stoichiometric organometallic bond-forming reactions. These fundamental studies will be described in detail, and their translation to practical applications (particularly in the context of the synthesis of PET imaging agents) will be discussed.
Host: Chem Talks
Melanie Sanford grew up in Providence, RI. She received her undergraduate degree in chemistry from Yale University in 1996 where she worked with Professor Bob Crabtree studying C–F bond functionalization. She then moved to Caltech where she worked with Professor Bob Grubbs investigating the mechanism of ruthenium-catalyzed olefin metathesis reactions. After receiving her PhD in 2001, she worked with Professor Jay Groves at Princeton University as an NIH post-doctoral fellow studying metalloporphyrin-catalyzed functionalization of olefins. Melanie has been a professor at the University of Michigan since the summer of 2003.
The Edward Mack, Jr. Lectures
Professor Edward Mack, Jr. was a long time faculty member of the Chemistry Department at The Ohio State University. After fourteen years as chairman, he resigned in October, 1955, to be devoted full time to teaching and research. Not long thereafter his friends and former students learned of his death in June, 1956.
Professor Mack's research interests included the determina- tion of the sizes and shapes of molecules from collision cross-sections using kinetic gas measurements. He also studied the rates and mechanisms of gas phase reactions, surface films, and biochemical problems. Professor Mack is remembered as a man of great energy and enthusiasm for research as well as his students.
Professor Mack became a member of the faculty at Ohio State in 1919 when he immediately began to take a personal interest in graduate students. He was their continual advocate, aiding his students through difficult years by soliciting grants from many companies and businesses. In many cases, he even took funds out of his own pocket for their support. Professor Mack was entirely dedicated to his graduate students, both scientifically and personally. In this spirit, the graduate students are responsible for every aspect of the Mack Memorial Award.
Graduate Students participate in the Mack Memorial Award by serving on the Mack Award's committee, nominating individuals, voting for the Mack Award recipient, and, of course, for attending the talks and joining the celebration.
2019 - Cynthia Friend
2018 - Peidong Yang
2017 - David MacMillan
2016 - Omar Yaghi
2015 - George Whitesides
2014 - Robert S. Langer
2013 - T. Don Tilley
2012 - Sunney Xie
2011 - Vincent Rotello
2010 - Chad A. Mirkin
Note: This lecture was made possible by financial support from the Dr. Robert H. Lawrence Jr. Endowed Fund in Chemistry, the Dr. Kurt L. Loening Endowment Fund in Chemical Nomenclature and Chemical Information, the Chemistry Lecture Fund, as well as numerous other donors.