Dennis Bong



Dennis Bong received a B.Sc. in chemistry from the University of California at Berkeley while working with Professor K. Peter C. Vollhardt and his Ph.D. from The Scripps Research Institute with Professor M. Reza Ghadiri. He then did a postdoctoral stint with Professor Ronald Breslow at Columbia University in New York and joined the chemistry faculty at The Ohio State University in 2004. He was promoted to Associate Professor in 2012.

Research Overview

Our research program is focussed on both the fundamental and applied aspects of organic chemistry at interfaces, particularly lipid membranes. We are pursuing new tools to illuminate lipid membrane biophysics and for controlled chemical delivery to living cells and tissues. Membrane transformations are used in Nature to control the release of chemical agents to designated in vivo targets; we seek to design synthetic lipid and polymer systems that will deliver chemical cargo in a similarly selective manner, predicated on an understanding of lipid assembly biophysics.

Research in the group is highly multidisciplinary: projects begins with organic synthesis and branch into biophysics, bioanalytical studies and cell biology. Researchers with these diverse backgrounds work together to investigate interfacial molecular recognition and its applications in biotechnology and materials science. To this end, our group pursues research in the design and organic synthesis of simple but potentially biologically interesting lipids, peptides, polymers and membrane assemblies.

Projects in the group are funded by grants from the National Science Foundation, industrial support on new renewable resource biomaterials, the Ohio Bioproducts Innovation Center and the Institute of Materials Research at the Ohio State University.

The Bong Research Group is currently seeking new graduate students.

Recent Publications

1. Gong, Y., Luo, Y. & Bong, D. Membrane activation: selective vesicle fusion via small molecule recognition. J. Am. Chem. Soc.128, 14430-14431 (2006).

2. Gong, Y., Ma, M., Luo, Y. & Bong, D. Functional determinants of a synthetic vesicle fusion system. J. Am. Chem. Soc. 130, 6196-6205 (2008).

3. Ma, M., Paredes, A. & Bong, D. Intra- and intermembrane pairwise molecular recognition between synthetic hydrogen-bonding phospholipids. J. Am. Chem. Soc. 130, 14456-14458 (2008).

4. Torres, O., Yuksel, D., Bernardina, M., Kumar, K. & Bong, D. Peptide tertiary structure nucleation by side-chain crosslinking with metal complexation and double "click" cycloaddition. ChemBioChem 9, 1701-1705 (2008).

5. Ma, M., Gong, Y. & Bong, D. Lipid Membrane Adhesion and Fusion Driven by Designed, Minimally Multivalent Hydrogen-Bonding Lipids. J. Am. Chem. Soc. 131, 16919-16926 (2009). 

Areas of Expertise
  • Biochemistry
  • Organic

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285 CBEC Building