Christopher Callam

Christopher Callam

Christopher Callam

Instructional Lab Supervisor, Associated Associate Professor

callam.1@osu.edu

614-292-0679

380C Celeste Laboratory
120 W 18th Ave
Columbus, OH 43210

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Areas of Expertise

  • Teaching Laboratory

Bio

Christopher Callam received his undergraduate Chemistry degree (BS)  from John Carroll University in 1998.  He obtained his Ph.D. in Organic Chemistry from The Ohio State University working under the supervision of Dr. Todd Lowary in 2003.  From 2003-2004, he was a Ruth L. Kirschstein NIH Post-Doctoral Research Fellow at the University of Pittsburgh working with Dr. Dennis Curran,  In 2004, he returned to the Department of Chemistry at The Ohio State University.

Research Overview

The general area of our research is focused on synthetic organic chemistry.  We are working on the synthesis of complex, biologically active organic molecules that have novel design and function starting from chiral carbohydrate templates.  Our two current synthetic targets are (+)-Pyrenolide-D and Courdamine-F.

We are also very interested in developing new applications for biocatalytic reducing agents. Biocatalytic methods are impressive since they must be performed in an aqueous medium (water).  Our research has been able to optimize the reductions of pro-chrial ketones and imines using legume seeds.  Excellent enantioselectivty (95-99.5% ee) was observed based on legume type (pea or bean). Initial results also indicate the type of legume (genus:family) can have significant effects on the selectivity; experiments with two different types of bean have allowed us to prepare alcohols in high enantiomertic excess of opposite configuration.  These experiments can be conducted with minimal specialized equipment, and without the need of oxygen/moisture sensitive regents or expensive catalysts.

We are also working on two collaborative research projects with Dr. Christopher Hadad.  We are developing synthetic pathways for small molecule chemical reactivators for protection from organophosphorus agents, including chemical nerve agents and pesticides.  We are also working on understanding biological distribution of these enzymatic systems by developing spin-probes for the in vivo detection of biological agents using trityl aryl radicals and electron paramagnetic resonance imaging.

Teaching

As the director of undergraduate organic laboratories, I have been heavily involved in various service activities for the Department, including management and mentoring of graduate and undergraduate teaching assistants, curriculum development, scheduling and enrollment for the organic course, development of new lab experiments and REEL modules.  I am interested in improving student understanding and incorporating technology into the organic chemistry lecture and laboratory.

Publications

Callam, C. S.; Lowary, T. L. “Total Synthesis of Methyl 4a-carba-D-arabinofuranosides.”  Org. Lett. 2000, 2, 167-169.

Callam, C. S.; Gadikota, R. R.; Lowary, T. L.  “An Efficient Synthesis of Methyl 2,3-anhydro-a-D-ribofuranoside.”  Carbohydr. Res. 2001, 330, 267-270.

Callam, C. S.; Lowary, T. L.  “Synthesis of Methyl 2,3,5-tri-O-benzoyl-a-D-arabinofuranoside in  the Organic Laboratory.”  J. Chem. Educ.  2001, 78, 73-74.

Gadikota, R. R.; Callam, C. S.; Lowary, T. L.  “Stereocontrolled Synthesis of 2,3-Anhydro-b-D-lyxofuranosyl Glycosides.”  Org. Lett.  2001, 3, 607-610.

Callam, C. S.; Lowary, T.L.  “Suzuki Cross Coupling Reactions: Synthesis of Unsymmetrical Biaryls in the Organic Laboratory.”  J. Chem. Educ. 2001, 78, 964-966.

Callam , C. S.; Gadikota, R. R.; Lowary, T. L.  “Sensitivity of 1JC1-H1 magnitudes to Anomeric Stereochemistry in 2,3-Anhydro-O-furanosides.”  J. Org. Chem.  2001, 66, 4549-4558.

Callam, C. S.; Singer, S. J.; Lowary, T. L.; Hadad, C. M. “Computational Analysis of the Potential Energy Surfaces of Glycerol in the Gas and Aqueous Phases.  Effects of Level of Theory, Basis Set, and Solvation on Strongly Intramolecularly Hydrogen-Bonded Systems.”  J. Am. Chem. Soc. 2001, 123, 11743-11754.

Callam, C. S.; Lowary, T. L. “Synthesis and Conformational Investigation of Methyl 4a-carba-D-arabinofuranosides.”  J. Org. Chem. 2001, 66, 8961-8972.

Gadikota, R. R.; Callam, C. S.; Lowary, T.L.  “The Total Synthesis of (6S,7S,9S,10S)-6,9-epoxynonadec-18-ene-7,10-diol and Formal synthesis of (+)-trans-Kumausyne from D-Arabinose.” J. Org. Chem. 2001, 66, 9046-9051.

Gadikota, R. R.; Callam, C. S.; Wagner, T., Del Friano, B.; Lowary, T. L.  “2,3-Anhydrosugars in Glycoside Bond Synthesis.  Highly Stereoselective Syntheses of Oligosaccharides Containing a- and b-Arabinofuranosyl Linkages.”  J. Am. Chem. Soc.  2003, 125, 4155-4165.

Callam, C. S.; Gadikota, R. R.; Krein, D. M.; Lowary, T. L.; “ 2,3-Anhydrosugars in Glycoside Bond Synthesis.  Low Temperature NMR and Computational Mechanistic Investigations.”  J. Am. Chem. Soc.  2003, 125, 13112-13119.

Gadikota, R. R.; Keller, A. I.; Callam, C. S.; Lowary, T. L.; “Efficient syntheses of trans-(+)-laurediol from carbohydrate precursors.”  Tetrahedron Assym.  2003, 14, 737-742.

Gadikota, R. R.; Callam, C. S.; Appelmelk, B. J.; Lowary, T. L.; “Synthesis of Oligosaccharide Fragments of Mannosylated Lipoarabinomannan Appropriately Functionalized for neoglyconjugate Preparation.” J. Carb. Chem.  2003, 22, 459-480.

Callam, C. S.; Gadikota, R. R.; Lowary, T. L. “An Efficient Route to Pyrimidine Nucleosides with the 2,3-anhydro-b-D-lyxofuranosyl stereochemistry.” Synlett.  2003, 9, 1271-1274.

Wagner, T. R.; Gadikota, R. R.; Callam, C. S.; Lowary, T. L. “1-(2’,3’-5’-O-benzoyl-b-D-lyxofuranosyl)-5-fluoro-uracil.”  Acta. Cryst.  2003, E59, o1063-o1065.

Darwish, O. S.; Callam, C. S.; Hadad, C. M.; Lowary, T. L.  “Regioselectivity in Alkylation Reactions of 1,2-O-Stannylene Acetals of D-Arabinofuranose.”  J. Carb. Chem.  2003, 22, 963-981.

Zhou, Q. Q.; Price, D. D.; Callam, C. S.; Woodruff, M. A., Verne, G. N. “Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome.” Journal of Pain. 2011, 12(2), 297-303

Zhou, Q. Q.; Price D. D.; Dreher K. L.; Pronold, B.; Callam C. S.; Sharma, J.: Verne, G. N.  “Localized Colonic Stem Cell Transplantation Enhances Tissue Regeneration in Murine Colitis.” Journal Cellular and Molecular Medicine.  2011, 10, 1582-1590.

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