Dan Conroy

Photo of Dan Conroy

Dan Conroy

Research Associate | NMR & EPR Laboratory Manager

conroy.120@osu.edu

(614) 292-5409

083 CBEC
151 W Woodruff Ave
Columbus, OH 43210

Google Map

Areas of Expertise

  • NMR Laboratory
  • Research Support Services

Biography

Dan was born and raised in the suburbs of Chicago, IL. He received a B.S. in Chemistry with an environmental chemistry concentration, in 2013, at the University of Illinois in Urbana-Champaign and conducted research under the tutelage of Dr. Chad Rienstra. He then arrived at The Ohio State University in 2013 to purse graduate studies in Physical Chemistry with a research focus on NMR spectroscopy, with Dr. Chris Jaroniec. Here, he developed methods for studying protein and nucleic acids using dynamic nuclear polarization (DNP) solid-state NMR spectroscopy. Upon completing his Ph.D. in 2019, Dan joined the ranks of Research Support Services to help manage the Chemistry & Biochemistry Department’s ever-growing NMR and EPR facility. 

Research Interests: 

  • Investigating insensitive species and low abundance states of biomolecules using dynamic nuclear polarization (DNP) solid-state NMR spectroscopy 

  • Quantifying electron concentrations for calibrating nitroxide DNP polarizing agents and indirectly observing reactive oxygen using a nitroxide spin-trap by EPR spectroscopy 

  • Structural elucidation and dynamics measurements of protein, nucleic acids, peptides, small molecules, and polymers using solution-state and solid-state NMR spectroscopy 

Relevant Publication list: 

Conroy, D.W.; Xu, Y.; Shi, H.; Gonzalez-Salguero, N.; Purusottam, R.; Shannon, M.D.; Al-Hashimi, H.M.; Jaroniec, C.P.; Characterizing Watson-Crick and Hoogsteen base-pairing in duplex DNA using dynamic nuclear polarization solid-state NMR: an application to nucleosomal DNA,  in preparation

Conroy, D.W.; Herbert, J.M.; Rosay, M.M.; Jaroniec, C.P.; Peptide-Based Biradicals for Dynamic Nuclear Polarization of Solid-State NMR Spectroscopy, in preparation.  

Wang H.; Gao, Z.; Liu, X.; Agarwal, P.; Zhao, S.; Conroy, D.W.; Ji, G.; Yu J.; Jaroniec, C.P.; Liu, Z.; Lu, X.; Li, X.; He, X. Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance, Nat. Commun2018, 9, 562.  

Conroy, D.W.; Jaroniec, C.P.; Radical Compounds and Methods of Using Thereof. US Patent Application 62/541,334, filed 2017. Patent Pending. 

People Filters: