PROTEIN RECEPTOR SIGNALING
Proteins on the surface and embedded with cellular membranes are key to communicating environmental signals to the machinery within cells, and are thus often drug targets. The ability to study the interaction of small molecules with receptors is a significant scientific challenge. By combining nanomaterials and state of the art spectroscopy and microscopy techniques, such as atomic force microscopy and tip-enhanced Raman scattering (TERS), we are able to monitor chemical signals associated with molecules interacting with specific proteins in intact cells. Understanding how molecules interact with signaling proteins offers promise to improve drug targeting as well as further investigate the role of membrane proteins in disease.
Underlying all the problems we investigate is the basic science relevant to the signal enhancements incorporated into our measurements. We are interested in understanding how nanomaterials interact with light, particularly with respect to how these properties alter the response from nearby molecules. This basic science serves as the basis for the development of future measurement techniques and other applications, such as photo-catalysts for CO2 reduction.
Sloan-Dennison, S.; Schultz, Z. D., “Label-Free Plasmonic Nanostar Probes to Illuminate In Vitro Membrane Receptor Recognition” Chemical Science, 2019 IN PRESS. DOI: 10.1039/C8SC05035J
Nguyen, A. H.; Deutsch, J. M.; Xiao, L.; Schultz, Z. D., Online Liquid Chromatography - Sheath-Flow Surface Enhanced Raman Detection of Phosphorylated Carbohydrates. Analytical Chemistry, 2018, 90(18), 11602-11609, DOI: 10.1021/acs.analchem.8b02907.
Nelson, D.A. and Schultz, Z.D.*, “Influence of Optically Rectified Electric Fields on the Plasmonic Photocatalysis of 4-Nitrothiophenol and 4-Aminothiophenol to 4,4-Dimercaptoazobenzene”, Journal of Physical Chemistry C, 2018, 122(15), 8581-8588, DOI: 10.1021/acs.jpcc.8b00662.
Xiao, L., Bailey, K.A., Wang, H., and Schultz, Z.D.*, “Probing Membrane Receptor - Ligand Specificity with Tip Enhanced Raman Scattering”, Analytical Chemistry, 2017, 89(17), 9091-9099, DOI: 10.1021/acs.analchem.7b01796.
Kim, J, Zeng, Z., Xiao, L., and Schultz, Z.D.*, “Elucidating Protein- Ligand Recognition with Combined Surface Plasmon Resonance and Surface Enhanced Raman Spectroscopy”, Analytical Chemistry, 2017, 89(24), 13074-13081, DOI: 10.1021/acs.analchem.7b04246.