PROTEIN RECEPTOR SIGNALING. Proteins on the surface and embedded with cellular membranes are key to communicating environmental signals to the machinery within cells, and are thus often drug targets. The ability to study the interaction of small molecules with receptors is a significant scientific challenge. By combining nanomaterials and state of the art spectroscopy and microscopy techniques, such as atomic force microscopy and tip-enhanced Raman scattering (TERS), we are able to monitor chemical signals associated with molecules interacting with specific proteins in intact cells. Understanding how molecules interact with signaling proteins offers promise to improve drug targeting as well as further investigate the role of membrane proteins in disease.
ACTIVE PLASMONICS. Underlying all the problems we investigate is the basic science relevant to the signal enhancements incorporated into our measurements. We are interested in understanding how nanomaterials interact with light, particularly with respect to how these properties alter the response from nearby molecules. This basic science serves as the basis for the development of future measurement techniques and other applications, such as photo-catalysts.
Xiao, L., Wang, H., and Schultz, Z.D.* “Selective Detection of RGD-Integrin Binding in Cancer Cells Using Tip Enhanced Raman Scattering Microscopy”, Analytical Chemistry, 2016, 88(12), 6547-6553, DOI: 10.1021/acs.analchem.6b01344.
Riordan, C.M., Jacobs, K.T., Negri, P., and Schultz, Z.D.*, “High Throughput Chemical Profiling in Urine by SERS”, Faraday Discussions, 2016, 187, 473-484, DOI: 10.1039/C5FD00155B
Kwasnieski, D.T.; Wang, H.; Schultz, Z.D.*, “Alkyl-Nitrile Adlayers as Probes of Plasmonically Induced Electric Fields.” Chemical Science, 2015.6(8), 4484 - 4494, DOI: 10.1039/C5SC01265A.
Negri, P., Jacobs, K.T., Dada, O.O., Schultz, Z.D.*, “Ultrasensitive SERS Flow Detector Using Hydrodynamic Focusing” Analytical Chemistry, 2013, 85(21), 10159-10166 DOI: 10.1021/ac401537k.
Asiala, S.M., Schultz, Z.D.* “Label-Free In Situ Detection of Individual Macromolecular Assemblies by Surface Enhanced Raman Scattering” Chemical Communications, 2013, 49(39), 4340-4342, DOI: 10.1039/C2CC37268A.